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Neurobiol."],"published-print":{"date-parts":[[2001,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Several features of male reproductive behavior are under the neural control of <jats:italic>fruitless<\/jats:italic> (<jats:italic>fru<\/jats:italic>) in <jats:italic>Drosophila melanogaster.<\/jats:italic> This gene is known to influence courtship steps prior to mating, due to the absence of attempted copulation in the behavioral repertoire of most types of <jats:italic>fru<\/jats:italic>\u2010mutant males. However, certain combinations of <jats:italic>fru<\/jats:italic> mutations allow for fertility. By analyzing such matings and their consequences, we uncovered two striking defects: mating times up to four times the normal average duration of copulation; and frequent infertility, regardless of the time of mating by a given transheterozygous <jats:italic>fru<\/jats:italic>\u2010mutant male. The lengthened copulation times may be connected with <jats:italic>fru<\/jats:italic>\u2010induced defects in the formation of a male\u2010specific abdominal muscle. Production of sperm and certain seminal fluid proteins are normal in these <jats:italic>fru<\/jats:italic> mutants. However, analysis of postmating qualities of females that copulated with transheterozygous mutants strongly implied defects in the ability of these males to transfer sperm and seminal fluids. Such abnormalities may be associated with certain serotonergic neurons in the abdominal ganglion in which production of 5HT is regulated by <jats:italic>fru.<\/jats:italic> These cells send processes to contractile muscles of the male's internal sex organs; such projection patterns are aberrant in the semifertile <jats:italic>fru<\/jats:italic> mutants. Therefore, the reproductive functions regulated by <jats:italic>fruitless<\/jats:italic> are expanded in their scope, encompassing not only the earliest stages of courtship behavior along with almost all subsequent steps in the behavioral sequence, but also more than one component of the culminating events. \u00a9 2001 John Wiley &amp; Sons, Inc. J Neurobiol 47: 121\u2013149, 2001<\/jats:p>","DOI":"10.1002\/neu.1021","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T21:28:49Z","timestamp":1030310929000},"page":"121-149","source":"Crossref","is-referenced-by-count":78,"title":["New reproductive anomalies in <i>fruitless<\/i>\u2010mutant <i>Drosophila<\/i> males: Extreme lengthening of mating durations and infertility correlated with defective serotonergic innervation of reproductive organs"],"prefix":"10.1002","volume":"47","author":[{"given":"Gyunghee","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Villella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara J.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey C.","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,3,30]]},"reference":[{"key":"e_1_2_1_2_1","article-title":"Control of copulation duration in Drosophila","author":"Acebes A","year":"2001","journal-title":"J Neurogenet"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","DOI":"10.1093\/genetics\/158.4.1569","article-title":"The sex determination gene fruitless, in addition to controlling male sexual behaviors in Drosophila, has sex\u2010nonspecific vital functions","author":"Anand A","year":"2001","journal-title":"Genetics"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.19.6.4405"},{"key":"e_1_2_1_5_1","first-page":"105","article-title":"Structure and ultrastructure of the male reproductive system in Drosophila melanogaster Meig. 2. 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