{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:14:28Z","timestamp":1791188068565,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T00:00:00Z","timestamp":1088640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurobiol."],"published-print":{"date-parts":[[2004,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Knockout (KO) mice lacking the orphan nuclear receptor steroidogenic factor 1 (SF\u20101) exhibit marked structural abnormalities of the ventromedial nucleus of the hypothalamus (VMH). In this study, we sought to determine the molecular mechanisms underlying the VMH abnormalities. To trace SF\u20101\u2010expressing neurons, we used a SF\u20101\/enhanced green fluorescent protein (eGFP) transgene. Although the total numbers of eGFP\u2010positive cells in wild\u2010type (WT) and SF\u20101 KO mice were indistinguishable, cells that normally localize precisely within the VMH were scattered more diffusely in adjacent regions in SF\u20101 KO mice. This abnormal distribution is likely due to the loss of SF\u20101 expression in VMH neurons rather than secondary effects of deficient steroidogenesis, as redistribution also was seen in mice with a CNS\u2010specific KO of SF\u20101. Thus, the absence of SF\u20101 alters the distribution of cells that normally form the VMH within the mediobasal hypothalamus. Consistent with this model, the hypothalamic expression patterns of the transcription factors islet\u20101 and nkx2.1 also were displaced in SF\u20101 KO mice. Independent of gene expression, birthdate analyses further suggested that cells with earlier birthdates were affected more severely by the loss of SF\u20101 than were later born cells. We conclude that the absence of SF\u20101 causes major changes in cellular arrangement within and around the developing VMH that result from altered cell migration. \u00a9 2004 Wiley Periodicals, Inc. J Neurobiol 60: 424\u2013436, 2004<\/jats:p>","DOI":"10.1002\/neu.20030","type":"journal-article","created":{"date-parts":[[2004,7,2]],"date-time":"2004-07-02T07:00:51Z","timestamp":1088751651000},"page":"424-436","source":"Crossref","is-referenced-by-count":69,"title":["Loss of steroidogenic factor 1 alters cellular topography in the mouse ventromedial nucleus of the hypothalamus"],"prefix":"10.1002","volume":"60","author":[{"given":"Aline M.","family":"Davis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne L.","family":"Seney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy R.","family":"Stallings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith 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