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In the present study we have used a brain and nasal septum coculture system to examine the role of target tissue on the peripheral trajectory of olfactory sensory axons. In cultures of isolated embryonic nasal septa, olfactory axons form numerous parallel fascicles that project caudally in the submucosa, as they do <jats:italic>in vivo<\/jats:italic>. The ventral axon fascicles in the septum, however, often fail to turn, and do not project dorsally towards the roof of the nasal cavity. The presence of olfactory bulb, cortical, or tectal tissue apposed to the caudal end of the septum rescued this phenotype, causing the ventral fascicles to follow a normal <jats:italic>in vivo<\/jats:italic>\u2010like trajectory. Ectopic placements of the explants revealed that brain tissue is not tropic for olfactory axons but appears to maintain the peripheral trajectory of growing axons in the nasal septum. Although primary olfactory axons are able to penetrate into olfactory bulb <jats:italic>in vitro<\/jats:italic>, they only superficially enter cortical tissue, whereas they do not grow into tectal explants. The ability of axons to differentially grow into different brain regions was shown to be unrelated to the migratory behavior of olfactory ensheathing cells, indicating that olfactory axons are directly responsive to guidance cues in the brain. \u00a9 2004 Wiley Periodicals, Inc. J Neurobiol, 2004<\/jats:p>","DOI":"10.1002\/neu.20060","type":"journal-article","created":{"date-parts":[[2004,7,6]],"date-time":"2004-07-06T21:01:28Z","timestamp":1089147688000},"page":"175-188","source":"Crossref","is-referenced-by-count":10,"title":["Target tissue influences the peripheral trajectory of mouse primary sensory olfactory axons"],"prefix":"10.1002","volume":"61","author":[{"given":"Melonie 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