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We have isolated pre\u2010 and post\u2010otic hindbrain segments and spinal segments of the mouse neural tube, when they form at embryonic day (E) 9, and grafted them into the same positions in stage\u2010matched chick hosts. Three days after grafting, <jats:italic>in vitro<\/jats:italic> recordings of the activity in the cranial nerves exiting the grafts indicate that a high frequency (HF) rhythm (order: 10 bursts\/min) is generated in post\u2010otic segments while more anterior pre\u2010otic and more posterior spinal territories generate a low frequency (LF) rhythm (order: 1 burst\/min). Comparison with homo\u2010specific grafting of corresponding chick segments points to conservation in mouse and chick of the link between the patterning of activities and the axial origin of the hindbrain segment. This HF rhythm is reminiscent of the respiratory rhythm known to appear at E15 in mice. We also report on pre\u2010\/post\u2010otic interactions. The pre\u2010otic rhombomere 5 prevents the emergence of the HF rhythm at E12. Although the nature of the interaction with r5 remains obscure, we propose that ontogeny of fetal\u2010like respiratory circuits relies on: (i) a selective developmental program enforcing HF rhythm generation, already set at E9 in post\u2010otic segments, and (ii) trans\u2010segmental interactions with pre\u2010otic territories that may control the time when this rhythm appears. \u00a9 2006 Wiley Periodicals, Inc. J Neurobiol, 2006<\/jats:p>","DOI":"10.1002\/neu.20271","type":"journal-article","created":{"date-parts":[[2006,9,11]],"date-time":"2006-09-11T21:55:19Z","timestamp":1158011719000},"page":"1285-1301","source":"Crossref","is-referenced-by-count":9,"title":["Pre\u2010\/post\u2010otic rhombomeric interactions control the emergence of a fetal\u2010like respiratory rhythm in the mouse 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