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Here we use RNAi and over\u2010expression to analyze the function of <jats:italic>torp4a<\/jats:italic>, the only <jats:italic>Drosophila<\/jats:italic> torsin. Targeted down\u2010regulation in the eye causes progressive degeneration of the retina. Conversely, over\u2010expression of <jats:italic>torp4a<\/jats:italic> protects from age\u2010related degeneration. In the retinas of young animals, a correlation with the lysosome\u2010related organelle, the pigment granule, is also observed. Lowering <jats:italic>torp4a<\/jats:italic> causes an increase in pigment granules, while over\u2010expression causes loss of granules. We have performed a screen for genetic interactors of <jats:italic>torp4a<\/jats:italic> identifying a number mutants, including two members of the AP\u20103 complex. Other genetic interactors found included genes related to actin and myosin function. Our findings implicate the <jats:italic>Drosophila<\/jats:italic> torsin, <jats:italic>torp4a<\/jats:italic>, to function with molecules consistent with already predicted roles in the endoplasmic reticulum\/nuclear envelope compartment, and have identified potential new interactions with AP\u20103 like components. \u00a9 2006 Wiley Periodicals, Inc. J Neurobiol, 2006<\/jats:p>","DOI":"10.1002\/neu.20313","type":"journal-article","created":{"date-parts":[[2006,9,11]],"date-time":"2006-09-11T21:54:21Z","timestamp":1158011661000},"page":"1338-1353","source":"Crossref","is-referenced-by-count":35,"title":["Down\u2010regulation of <i>torp4a<\/i>, encoding the <i>Drosophila<\/i> homologue of torsinA, results in increased neuronal degeneration"],"prefix":"10.1002","volume":"66","author":[{"given":"Nara I.","family":"Muraro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin G.","family":"Moffat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,9,11]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"36","article-title":"Image processing with ImageJ","volume":"11","author":"Abramoff MD","year":"2004","journal-title":"Biophotonics 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