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Transport velocities of two profile loci can be accurately described and a quantitative profile analysis is possible after profile normalization. Results from such studies indicate that: (<jats:italic>1<\/jats:italic>) peak amplitudes decrease exponentially as a function of distance from the olfactory mucosa according to the equation <jats:italic>p<\/jats:italic> = 2130 exp (\u2013 0.109<jats:italic>x<\/jats:italic>); (<jats:italic>2<\/jats:italic>) the wavefront base and the peak apex loci move at rates of 221 \u00b1 2 and 201 \u00b1 4 mm\/day, respectively (at 23\u00b0C), revealing a peak dispersion or broadening during transport; (<jats:italic>3<\/jats:italic>) the broadening is asymmetric with material shifting to the rear of the peak; (<jats:italic>4<\/jats:italic>) plateau regions are established behind the peak with material deposited by the peak; (<jats:italic>5<\/jats:italic>) only 20% of the total radioactivity in a cut nerve reaches the nerve terminals in the rapid transport peak while 80% is deposited along the axon; (<jats:italic>6<\/jats:italic>) profile areas from cut nerves decrease and lose 15% of their activity in 20 hr, while intact nerve profiles increase 10% in 16 hr due to continued somal contribution to the profile; (<jats:italic>7<\/jats:italic>) the displacement of the wavefront base (WFB) and peak apex (PA) profile loci can be described by the functions<jats:disp-formula>\n\n<\/jats:disp-formula>\n(<jats:italic>8<\/jats:italic>) transport velocities are linear functions of temperature between 10 and 25\u00b0C and increase 370% in that range. A linear extrapolation of the WFB and PA functions to 37\u00b0C yields 410 and 377 mm\/day, respectively.<\/jats:p>","DOI":"10.1002\/neu.480060208","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T03:50:23Z","timestamp":1104551423000},"page":"213-232","source":"Crossref","is-referenced-by-count":80,"title":["A quantitative analysis of isotope concentration profiles and rapid transport velocities in the C\u2010fibers of the garfish olfactory nerve"],"prefix":"10.1002","volume":"6","author":[{"given":"Guenter W.","family":"Gross","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lloyd M.","family":"Beidler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.70.5.1521"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(71)90138-7"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-8109-9_4"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(73)90852-4"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1101\/SQB.1965.030.01.006"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.172.3986.952"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(73)90006-1"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1971.tb11965.x"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/neu.480020409"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.64.2.512"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/neu.480010404"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(72)90187-4"},{"key":"e_1_2_1_14_1","volume-title":"Dynamics of Chromatography Pt I: Principles and Theory","author":"Giddings J. 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