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The enzymes named and also the uptake of [<jats:sup>14<\/jats:sup>C]adenine by incubated tissue samples were more active with hypothalamic than with neocortical tissues. On superfusion with glucose\u2010bicarbonate saline after assimilating [<jats:sup>14<\/jats:sup>C]adenine, the hypothalamic tissues released about 0.2% of their <jats:sup>14<\/jats:sup>C content per minute. This release was increased fourfold with electrical excitation but the presence of 0.25 \u03bcU<jats:italic>M<\/jats:italic> tetrodotoxin prevented most of this increase. The compounds released during superfusion and electrical stimulation were preponderantly hypoxanthine, inosine, and adenosine, with only small amounts of adenine nucleotides. The output of all these compounds increased during the period of stimulation and also the proportion of adenine nucleotides increased when stimulation was carried out in the presence of tetrodotoxin. The output of the nucleotides and adenosine increased more promptly when stimulated than did that of the other compounds named. The results are discussed in terms of the metabolic roles of the enzymes concerned, and in relation to whether the enzymes are acting on intracellular or extracellular substrates.<\/jats:p>","DOI":"10.1002\/neu.480070204","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T03:53:10Z","timestamp":1104551590000},"page":"109-122","source":"Crossref","is-referenced-by-count":18,"title":["The metabolism of adenine derivatives in different parts of the brain of the rat, and their release from hypothalamic preparations on excitation"],"prefix":"10.1002","volume":"7","author":[{"given":"Man\u2010Chi","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry","family":"McIlwain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Pull","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)70226-3"},{"key":"e_1_2_1_3_1","first-page":"509","article-title":"Purinergic nerves","volume":"24","author":"Burnstock G.","year":"1972","journal-title":"Pharmacol. 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