{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T23:13:50Z","timestamp":1771629230899,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,11]],"date-time":"2004-10-11T00:00:00Z","timestamp":1097452800000},"content-version":"vor","delay-in-days":10390,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurobiol."],"published-print":{"date-parts":[[1976,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Membrane potentials, cable parameters, and component resting conductances were measured in extensor digitorum longus (EDL) muscle fibers from adult rats <jats:italic>in vitro<\/jats:italic> at 24\u00b0C, after 15 to 18 days of denervation by nerve section, and at seven to ten days following epineural injection of 100 to 450 \u03bcg of colchicine in the peroneal nerve. The denervated muscles were paralyzed throughout the experimental period, whereas the colchicine\u2010treated preparations showed no clinical paralysis except for the first day or two. The EDL from the untreated side served as a control.<\/jats:p><jats:p>Both the denervated and colchicine\u2010treated fibers were depolarized, showed signs of fibrillation, had tetrodotoxin\u2010resistant action potentials, and membrane resistance was increased two\u2010 to sevenfold. In the denervated fibers, mean chloride conductance <jats:italic>G<\/jats:italic><jats:sub>Cl<\/jats:sub> dropped from a control value of 3196 to 596 \u03bcmhos\/cm<jats:sup>2<\/jats:sup> while mean potassium conductance <jats:italic>G<\/jats:italic><jats:sub>K<\/jats:sub> showed a tendency to rise from 260 to 332 \u03bcmhos\/cm<jats:sup>2<\/jats:sup>. Colchicine\u2010treated fibers while showing a similar fall in mean <jats:italic>G<\/jats:italic><jats:sub>Cl<\/jats:sub> from 2993 to 1066 \u03bcmhos\/cm<jats:sup>2<\/jats:sup>, also showed a significant fall in mean <jats:italic>G<\/jats:italic><jats:sub>K<\/jats:sub> from 213 to 116 \u03bcmhos\/cm<jats:sup>2<\/jats:sup>.<\/jats:p><jats:p>It was concluded that factors transported by the microtubular system are important for the maintenance of the high resting <jats:italic>G<\/jats:italic><jats:sub>Cl<\/jats:sub> of mammalian skeletal muscle fibers.<\/jats:p>","DOI":"10.1002\/neu.480070305","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T03:53:00Z","timestamp":1104551580000},"page":"221-228","source":"Crossref","is-referenced-by-count":39,"title":["Effects of denervation and colchicine treatment on the chloride conductance of rat skeletal muscle fibers"],"prefix":"10.1002","volume":"7","author":[{"given":"D.","family":"Camerino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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