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Cuffs soaked in a 10 m<jats:italic>M<\/jats:italic>, but not 0.1 m<jats:italic>M<\/jats:italic> or 1 m<jats:italic>M<\/jats:italic>, concentration of TFP applied locally around the vagus nerve <jats:italic>in vivo<\/jats:italic> blocked both fast and slow AXT, as measured by the accumulation of <jats:sup>3<\/jats:sup>H\u2010labeled proteins. <jats:italic>In vitro<\/jats:italic>, fast AXT was affected by 0.1 m<jats:italic>M<\/jats:italic> TFP. The TFP cuff treatment caused a reduction in the number of axonal microtubules (MT) whereas cuffs soaked in saline had no effect. The levels of ATP, ADP, and AMP were not significantly lowered by the TFP treatment. The results suggest that both fast and slow AXT are sensitive to TFP treatment, and that the axonal MT\u2010system may be the main target of the drug.<\/jats:p>","DOI":"10.1002\/neu.480180304","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T04:47:24Z","timestamp":1104554844000},"page":"283-293","source":"Crossref","is-referenced-by-count":6,"title":["The effects of trifluoperazine on fast and slow axonal transport in the rabbit vagus nerve"],"prefix":"10.1002","volume":"18","author":[{"given":"Per","family":"Ekstr\u00f6m","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Kanje","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. 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