{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T23:03:26Z","timestamp":1705100606785},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2004,10,11]],"date-time":"2004-10-11T00:00:00Z","timestamp":1097452800000},"content-version":"vor","delay-in-days":5793,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurobiol."],"published-print":{"date-parts":[[1988,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In adult <jats:italic>Hirudo medicinalis<\/jats:italic>, the segmental ganglia (SG) of the fifth and sixth body segments contain a few hundred more cells than the other segmental ganglia of the body (Macagno, 1980). These ganglia innervate the sex organs and are known as the sex SG. As shown here, these cells are stained by neuron\u2010specific antibodies. Cell counts at several developmental stages reveal that the extra cells are added exclusively to the sex SG, and that this addition occurs gradually and almost entirely postembryonically (embryogenesis ends at 30 days of development). Hence, we refer to them as PE cells. Until 16 days of development, deleting the male genitalia or disconnecting them from the sex ganglia results in a complete absence of the PE cells. From 16 days onward, the generation of the PE cells is independent of the male genitalia. No PE cells appear in non\u2010sex SG that innervate male genitalia transplanted to ectopic locations at 10 days or later, indicating that as early as about 10 days of development sex SG are different from other SG in their ability to acquire PE cells. These data suggest that the PE cells are generated within the sex SG, in a process that is triggered by an interaction with the male genitalia and mediated through the innervation of the organs by these ganglia.<\/jats:p>","DOI":"10.1002\/neu.480190805","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T03:47:24Z","timestamp":1104551244000},"page":"707-726","source":"Crossref","is-referenced-by-count":23,"title":["The role of the sexual organs in the generation of postembryonic neurons in the leech <i>Hirudo medicinalis<\/i>"],"prefix":"10.1002","volume":"19","author":[{"given":"Carlos A.","family":"Baptista","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo R.","family":"Macagno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,11]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"197","volume-title":"Developmental Neurobiology","author":"Altman J.","year":"1970"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.03.030180.000525"},{"key":"e_1_2_1_4_1","first-page":"107","article-title":"Embryogenesis of an insect nervous system. I. A map of thoracic and abdominal neuroblasts in Locusta migratoria","volume":"35","author":"Bate M.","year":"1976","journal-title":"J. Embryol. Exp. Morphol."},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902550407"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"4107","DOI":"10.1523\/JNEUROSCI.07-12-04107.1987","article-title":"Postembryonic neurogenesis in the CNS of the tobacco hornworm, Manduca sexta. II. Hormonal control of imaginal nest cell degeneration and differentiation during metamorphosis","volume":"7","author":"Booker R.","year":"1987","journal-title":"J. Neurosci."},{"key":"e_1_2_1_7_1","first-page":"116","article-title":"A quantitative analysis of the development of CNS in juvenile Aplysia","volume":"17","author":"Cash D.","year":"1987","journal-title":"Proc. Soc. Neurosci."},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00605238"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6474175"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(83)90025-5"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-2037-1_7"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/neu.480180105"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.8.2390"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/icb\/6.2.251"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1400960305"},{"key":"e_1_2_1_16_1","first-page":"39","article-title":"Naturally occuring neuronal death in vertebrates","volume":"1","author":"Hamburger V.","year":"1982","journal-title":"Neurosci. Comm."},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1523\/JNEUROSCI.06-03-00867.1986","article-title":"Migration of neuroblasts along preexisting axonal tracts during prenatal cerebellar development","volume":"6","author":"Hynes R. O.","year":"1986","journal-title":"J. Neurosci."},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.04-05-01225.1984"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1523\/JNEUROSCI.07-09-02618.1987","article-title":"Morphological changes in leech Retzius neurons after target contact during embryogenesis","volume":"7","author":"Jellies J.","year":"1987","journal-title":"J. Neurosci."},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902050208"},{"key":"e_1_2_1_21_1","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1523\/JNEUROSCI.05-09-02301.1985","article-title":"FMRF\u2010amide like substances in the leech. I. Immunocytochemical localization","volume":"5","author":"Kuhlman J. R.","year":"1985","journal-title":"J. Neurosci."},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901900206"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.8.2746"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(83)90375-X"},{"key":"e_1_2_1_25_1","volume-title":"Neurobiology of the Leech","author":"Muller K. J.","year":"1981"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902660108"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6474166"},{"key":"e_1_2_1_28_1","doi-asserted-by":"crossref","first-page":"3088","DOI":"10.1523\/JNEUROSCI.05-11-03088.1985","article-title":"Cells born in adult canary forebrain are local interneurons","volume":"5","author":"Paton J. A.","year":"1985","journal-title":"J. Neurosci."},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901450105"},{"key":"e_1_2_1_30_1","first-page":"345","volume-title":"Leech Biology and Behaviour","author":"Sawyer R. T.","year":"1986"},{"key":"e_1_2_1_31_1","unstructured":"Stewart R. R.(1985). The genesis of segmental differences in the nervous system of two species of leeches. PhD Thesis Columbia University New York N.Y."},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902530211"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.06-09-02736.1986"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.07.030184.001131"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(88)90067-X"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(78)90029-5"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.11.030188.002231"},{"key":"e_1_2_1_38_1","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1152\/jn.1979.42.2.455","article-title":"Identifiable neurons controlling penile eversion in the leech","volume":"42","author":"Zipser B.","year":"1979","journal-title":"J. Neurophys."}],"container-title":["Journal of Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fneu.480190805","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/neu.480190805","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T15:31:04Z","timestamp":1697902264000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/neu.480190805"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,12]]},"references-count":37,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1988,12]]}},"alternative-id":["10.1002\/neu.480190805"],"URL":"https:\/\/doi.org\/10.1002\/neu.480190805","archive":["Portico"],"relation":{},"ISSN":["0022-3034","1097-4695"],"issn-type":[{"value":"0022-3034","type":"print"},{"value":"1097-4695","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,12]]}}}