{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T10:29:25Z","timestamp":1790850565886,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,10,11]],"date-time":"2004-10-11T00:00:00Z","timestamp":1097452800000},"content-version":"vor","delay-in-days":5762,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurobiol."],"published-print":{"date-parts":[[1989,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To study the effect of protein synthesis inhibition on long\u2010term sensitization of the gill\u2010 and siphon\u2010withdrawal reflex of <jats:italic>Aplysia<\/jats:italic>, we have developed an isolated reflex preparation in which we could expose the inhibitor to only that part of the central nervous system involved in mediating the reflex and not to the other parts of the animal's central nervous system, thus minimizing the possible systemic side effects. We have found that long\u2010term sensitization can be obtained in the isolated gill reflex, and that this long\u2010term process, but not the short\u2010term process, is blocked selectively by anisomycin, a reversible inhibitor of protein synthesis. Moreover, to obtain this blockade of long\u2010term sensitization, this drug need only be applied during the training procedure.<\/jats:p>","DOI":"10.1002\/neu.480200102","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T03:47:24Z","timestamp":1104551244000},"page":"1-9","source":"Crossref","is-referenced-by-count":181,"title":["Inhibitor of protein synthesis blocks longterm behavioral sensitization in the isolated gill\u2010withdrawal reflex of <i>Aplysia<\/i>"],"prefix":"10.1002","volume":"20","author":[{"given":"V. F.","family":"Castellucci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Blumenfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Goelet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. R.","family":"Kandel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-8109-9_26"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-3060-8_10"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6093258"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6828885"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","unstructured":"Bailey C. H. andChen M.(1988). Long\u2010term sensitization in Aplysia modulates the total number of varicosities of single identified sensory neurons.Proc. Natl. Acad. Sci. (USA) in press.","DOI":"10.1073\/pnas.85.7.2373"},{"key":"e_1_2_1_7_1","first-page":"909","article-title":"Serotonin (5\u2010HT) causes changes in protein synthesis in plural sensory neurons from","volume":"14","author":"Barzilai A.","year":"1988","journal-title":"Aplysia. Soc. Neurosci. Abstr."},{"key":"e_1_2_1_8_1","first-page":"379","volume-title":"Short\u2010Term Memory","author":"Barondes S. H.","year":"1975"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.214854"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(88)90080-3"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.167.3926.1745"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(88)90138-5"},{"key":"e_1_2_1_13_1","first-page":"389","article-title":"Inhibition of protein synthesis blocks long\u2010term plasticity in identified B\u2010photoreceptors in Hermissenda","volume":"13","author":"Crow T.","year":"1987","journal-title":"Soc. Neurosci. Abstr."},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1523\/JNEUROSCI.07-07-02232.1987","article-title":"Serotonin produces long\u2010term changes in the excitability of Aplysia sensory neurons in culture that depends on new protein synthesis","volume":"7","author":"Dale N.","year":"1987","journal-title":"J. Neurosci."},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2892269"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.96.3.518"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.890010112"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.141.3575.57"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.23.8266"},{"key":"e_1_2_1_20_1","first-page":"510","article-title":"Sensitizing stimuli reduce the effectiveness of the L30 inhibitory interneurons in the siphon withdrawal reflex circuit of Aplysia","volume":"10","author":"Frost W. N.","year":"1984","journal-title":"Soc. Neurosci. Abstr."},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/322419a0"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/329062a0"},{"key":"e_1_2_1_23_1","first-page":"470","volume-title":"Neurobiology of Learning and Memory","author":"Greenough W. T.","year":"1984"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(88)90139-7"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3775383"},{"key":"e_1_2_1_26_1","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1523\/JNEUROSCI.06-03-00759.1986","article-title":"Synaptic plasticity in vitro: Cell culture of identified Aplysia neurons mediating short\u2010term habituation and sensitization","volume":"6","author":"Rayport S. G.","year":"1986","journal-title":"J. Neurosci."},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2433766"},{"key":"e_1_2_1_28_1","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1152\/jn.1971.34.6.939","article-title":"Functioning of identified neurons and synapses in abdominal ganglion of Aplysia in absence of protein synthesis","volume":"34","author":"Schwartz J. H.","year":"1971","journal-title":"J. Neurophysiol."},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.04-12-03080.1984"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(85)91299-5"},{"key":"e_1_2_1_31_1","first-page":"909","article-title":"Serotonin (5HT) causes a persistent increase in protein phosphorylation that is transcription\u2010dependent: A molecular mechanism contributing to long\u2010term sensitization in Aplysia sensory neurons","volume":"14","author":"Sweatt J. D.","year":"1988","journal-title":"Soc. Neurosci. Abstr."}],"container-title":["Journal of Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fneu.480200102","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/neu.480200102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T20:29:11Z","timestamp":1698006551000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/neu.480200102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,1]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1989,1]]}},"alternative-id":["10.1002\/neu.480200102"],"URL":"https:\/\/doi.org\/10.1002\/neu.480200102","archive":["Portico"],"relation":{},"ISSN":["0022-3034","1097-4695"],"issn-type":[{"value":"0022-3034","type":"print"},{"value":"1097-4695","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,1]]}}}