{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T06:07:37Z","timestamp":1785391657642,"version":"3.55.0"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2004,10,11]],"date-time":"2004-10-11T00:00:00Z","timestamp":1097452800000},"content-version":"vor","delay-in-days":4759,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurobiol."],"published-print":{"date-parts":[[1991,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In diandric sex\u2010reversing fishes, sexually active males and females (primary phase) regularly transform into an alternative reproductive morph, terminal\u2010phase males, that are morphologically and behaviorally distinct. The transformation from primary to terminal phase is associated with a twofold increase in the number of luteinizing hormone\u2010releasing hormone (LHRH) immunopositive cells in the forebrain preoptic area, a region involved in both the initial development and daily control of reproductive physiology and behavior. We now show that implants of 11\u2010ketotestosterone induce increases in LHRH cell number in both primary phase sexes to the level observed in field\u2010collected terminal phase males. Conversely, gonadal steroids had no effect on the number of LHRH preoptic cells in terminal phase males, suggesting that this is indeed a <jats:italic>terminal<\/jats:italic> stage in the development of this species. These results demonstrate that transition to the terminal phase by both sexes involves a parallel and convergent change in LHRH cell number, which utilizes an evolutionarily conserved mechanism of sexual differentiation: the inductive effects of gonadal steroid hormones.<\/jats:p>","DOI":"10.1002\/neu.480220708","type":"journal-article","created":{"date-parts":[[2005,5,27]],"date-time":"2005-05-27T21:59:48Z","timestamp":1117231188000},"page":"734-741","source":"Crossref","is-referenced-by-count":93,"title":["Gonadal steroids affect LHRH preoptic cell number in a sex\/role changing fish"],"prefix":"10.1002","volume":"22","author":[{"given":"Matthew S.","family":"Grober","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivor M. D.","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew H.","family":"Bass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000114359"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/neu.480210802"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.24.9295"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-6480(91)90120-U"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-3472(86)80219-6"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/neu.480210804"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/icb\/24.3.809"},{"key":"e_1_2_1_9_1","unstructured":"Diener D. R.(1976).Hermaphroditism in fish: a comparative study of the reproductive biology and endocrinology of the California Labridae. Doctoral Dissertation Scripps Institute of Oceanography University of California San Diego."},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(81)90112-X"},{"key":"e_1_2_1_11_1","first-page":"896","article-title":"The spawning, growth, and general behavior of the bluehaead wrasse, Thalassoma bifasciatum (Pisces: Labridae)","volume":"15","author":"Feddern H. A.","year":"1965","journal-title":"Bull. Mar. Sci."},{"key":"e_1_2_1_12_1","first-page":"1200","article-title":"Effect of gonadectomy on GnRH cells in the nervus terminalis and preoptic area in male african cichlids, Haplochromis burtoni","volume":"495","author":"Francis R. C.","year":"1990","journal-title":"Soc. Neurosci. Abstr."},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/neu.480200703"},{"key":"e_1_2_1_14_1","unstructured":"Grober M. S. Myers D. Myers T.andBass A.(1991). GnRH in the sexually polymorphic teleost fish Porichthys notatus: immunocytochemistry and in situ hybridization. Soc. Neurosci. Abst. 129.11."},{"key":"e_1_2_1_15_1","article-title":"Neuronal correlates of sex\/role change in labrid fishes: LHRH\u2010like immunoreactivity","author":"Halvorsen S. W.","year":"1991","journal-title":"Brain Behav. Evol."},{"key":"e_1_2_1_16_1","first-page":"1327","article-title":"LHRH\u2010positive preoptic cells in a sex reversing fish: sexual polymorphism and modulation by gonadal steroid hormones","volume":"548","author":"Halvorsen S. W.","year":"1990","journal-title":"Soc. Neurosci. Abstr."},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(87)91567-8"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1402400211"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00217881"},{"key":"e_1_2_1_20_1","unstructured":"Hoffman S. G.(1980).Sex\u2010related social mating and foraging behavior in some sequentially hermaphroditic reef fishes. Doctoral Dissertation University of California Santa Barbara."},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00219208"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.2307\/1444343"},{"key":"e_1_2_1_23_1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1093\/genetics\/89.1.79","article-title":"A sexlinked gene controlling the onset of sexual maturity in female and male platyfish (Xiphophorus maculatus), fecundity in females and adult size in males","volume":"89","author":"Halvorsen S. W.","year":"1978","journal-title":"Genetics"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0196-9781(87)90049-0"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1402520207"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1095-8649.1988.tb05376.x"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/298468a0"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3097822"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00001282"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903000406"},{"key":"e_1_2_1_31_1","first-page":"97","volume-title":"Fish Physiology, Vol. IX","author":"Peter R. E.","year":"1983"},{"key":"e_1_2_1_32_1","first-page":"550","article-title":"Spontaneous and hormone\u2010induced sex\u2010inversion in wrasses (Labridae)","volume":"39","author":"Reinboth R.","year":"1975","journal-title":"Pubbl. Staz. Zool. Napoli"},{"key":"e_1_2_1_33_1","first-page":"579","volume-title":"Current Trends in Comparative Endocrinology","author":"Reinboth R.","year":"1985"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(89)90045-4"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00293262"},{"key":"e_1_2_1_36_1","first-page":"519","article-title":"The influence of androgen administration on the structure and function of the brain\u2010pituitarygonad axis of sexually immature platyfish, Xiphophorus maculatus","volume":"245","author":"Schareibman M. P.","year":"1986","journal-title":"Cell Tiss. Res."},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/338161a0"},{"key":"e_1_2_1_38_1","first-page":"103","volume-title":"Fish Reproduction: Strategies and Tactics","author":"Shapiro D. Y.","year":"1984"},{"key":"e_1_2_1_39_1","first-page":"1283","volume-title":"The Physiology of Reproduction","author":"Silverman A.\u2010J.","year":"1988"},{"key":"e_1_2_1_40_1","volume-title":"Biometry","author":"Halvorsen S. W.","year":"1981"},{"key":"e_1_2_1_41_1","first-page":"125","article-title":"Hormonal control of sexually dimorphic pigmentation of Thalassoma bifasciatum","volume":"40","author":"Stoll L. M.","year":"1955","journal-title":"Zoologica"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-6480(74)90178-6"},{"key":"e_1_2_1_43_1","first-page":"204","volume-title":"Reproduction in Reef Fishes","author":"Thresher R. W.","year":"1984"},{"key":"e_1_2_1_44_1","first-page":"128","article-title":"Mating behavior and hermaphroditism in coral reef fishes","volume":"72","author":"Warner R. R.","year":"1982","journal-title":"Am. Sci."},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.2307\/1936747"},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1188360"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-6480(77)90184-8"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(89)90065-1"},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-0115(86)90161-8"},{"key":"e_1_2_1_50_1","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1093\/icb\/26.4.951","article-title":"Multi\u2010independent actions of peptides in the brain: LHRH, MIF\u20101 and CRF","volume":"26","author":"Halvorsen S. W.","year":"1986","journal-title":"Am. Zool."},{"key":"e_1_2_1_51_1","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.2307\/2409364","article-title":"Genetic basis for alternative reproductive tactics in the pygmy swordtail, Xiphophorus nigrensis","volume":"43","author":"Halvorsen S. W.","year":"1989","journal-title":"Evolution"}],"container-title":["Journal of Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fneu.480220708","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/neu.480220708","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T01:51:28Z","timestamp":1698025888000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/neu.480220708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,10]]},"references-count":50,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1991,10]]}},"alternative-id":["10.1002\/neu.480220708"],"URL":"https:\/\/doi.org\/10.1002\/neu.480220708","archive":["Portico"],"relation":{},"ISSN":["0022-3034","1097-4695"],"issn-type":[{"value":"0022-3034","type":"print"},{"value":"1097-4695","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,10]]}}}