{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T13:11:40Z","timestamp":1698066700644},"reference-count":46,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2004,10,11]],"date-time":"2004-10-11T00:00:00Z","timestamp":1097452800000},"content-version":"vor","delay-in-days":4728,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurobiol."],"published-print":{"date-parts":[[1991,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In male rats, methionine\u2010enkephalin immunoreactivity (enkephalin\u2010ir) has been observed in the dorsal lateral nucleus (DLN), a longitudinal pool of motoneurons in the lumbar spinal cord. Within the DLN a mediodorsal crescent of intense enkephalin\u2010ir staining surrounds the motoneurons innervating the ischiocavernosus muscle of the penis, which suggests a function of the enkephalinergic afferents in male copulatory activities. The present study attempted to determine the roles of gender and adult exposure to androgen in shaping the striking subnuclear distribution of enkephalin\u2010ir. Transverse sections through L5\u20136 were obtained from mature male and female rats that were gonadally intact, gonadectomized, or gonadectomized and treated with testosterone, as well as from male rats genetically deficient in androgen receptors (Tfm). The sections were incubated with primary antiserum raised against methionine enkephalin and bound antibodies were visualized using the avidin\u2010biotin peroxidase technique. A microphotometer was used to compare the staining density in laminae I\u2010II of the dorsal horn, ventral grey matter, and the DLN. In all groups the DLN stained more darkly than the ventral grey, demonstrating the presence of enkephalin\u2010ir in the DLN regardless of gender or exposure to androgen. However, the mediodorsal crescent of dense staining in the DLN was obvious only in gonadally intact males, while the entire DLN stained darkly in both sexes of gonadectomized rats treated with androgen. Therefore, the preferential distribution of enkephalin\u2010ir in the mediodorsal crescent of the DLN is sexually dimorphic though the overall content of enkephalin\u2010ir within the DLN responds to androgen.<\/jats:p>","DOI":"10.1002\/neu.480220808","type":"journal-article","created":{"date-parts":[[2005,5,27]],"date-time":"2005-05-27T21:20:51Z","timestamp":1117228851000},"page":"873-881","source":"Crossref","is-referenced-by-count":1,"title":["Sexually dimorphic, androgen sensitive, enkephalinergic afferents to a lumbar motor nucleus of rats"],"prefix":"10.1002","volume":"22","author":[{"given":"Arthur","family":"Coquelin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul E.","family":"Micevych","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur P.","family":"Arnold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490280307"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1152\/physrev.1967.47.2.289","article-title":"Cerebral and hormonal control of reflexive mechanisms involved in copulatory behavior","volume":"47","author":"Beach F. 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