{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:12:29Z","timestamp":1790770349159,"version":"4.1.0"},"reference-count":60,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,11]],"date-time":"2004-10-11T00:00:00Z","timestamp":1097452800000},"content-version":"vor","delay-in-days":4242,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurobiol."],"published-print":{"date-parts":[[1993,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Following injury of sciatic motor axons in the rat, the rate of axonal outgrowth is faster if there has been a prior \u201cconditioning\u201d axotomy. The acceleration of outgrowth is due to an acceleration of SCb, the rate [slow (SC)] component of axonal transport that carries cytomatrix proteins; this occurs throughout the axon by 7 days after the conditioning axotomy (Jacob and McQuarrie, 1991a, <jats:italic>J. Neurobiol.<\/jats:italic> 22:570\u2013583). To further characterize the conditioning lesion effect (CLE), it is important to know (1) the minimum effective conditioning interval (time between conditioning and testing lesions), (2) whether the cell body reaction is required, and (3) whether outgrowth accelerates after a <jats:italic>single<\/jats:italic> axotomy. Outgrowth distances were measured by radiolabeling all newly synthesized neuronal proteins and detecting those carried to growth cones by fast axonal transport. When the conditioning and testing lesions were made simultaneously (0 day conditioning interval), there was no CLE. With a conditioning interval of 3 days, there was a shortening of the initial delay (before the onset of outgrowth) without a change in outgrowth rate. With conditioning intervals of 7, 14, and 21 days, the rates of outgrowth were increased by 8%, 22%, and 11%, respectively. To determine whether the cell body reaction to axotomy is necessary for the CLE, a nonaxotomizing stimulus to axonal growth (partial denervation) was used in place of a conditioning axotomy. This had no effect on the rate of outgrowth from a testing lesion made 14 days later. Finally, we examined the possibility that outgrowth accelerates after a single lesion. Outgrowth was faster at 6\u20139 days after axotomy than at 3\u20136 days (<jats:italic>p<\/jats:italic> &lt; 0.001), and accelerated further at 9\u201312 days (<jats:italic>p<\/jats:italic> &lt; 0.001). We conclude that (1) the shortest effective conditioning interval is 3 days; (2) the cell body reaction is necessary for the CLE; (3) axonal outgrowth from a single axotomy accelerates in concert with the anabolic phase of the cell body reaction. The SCb motor is, in turn, upregulated by this reaction. This suggests that the SCb motor responds to a fast\u2010transported signal that is a product of the cell body reaction. \u00a9 1993 John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/neu.480240308","type":"journal-article","created":{"date-parts":[[2005,5,27]],"date-time":"2005-05-27T22:04:27Z","timestamp":1117231467000},"page":"356-367","source":"Crossref","is-referenced-by-count":50,"title":["Acceleration of axonal outgrowth in rat sciatic nerve at one week after axotomy"],"prefix":"10.1002","volume":"24","author":[{"given":"Jane M.","family":"Jacob","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irvine G.","family":"McQuarrie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,11]]},"reference":[{"key":"e_1_2_1_2_1","volume-title":"Statistical Methods in Medical Research","author":"Armitage P.","year":"1971"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/321788a0"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(86)90108-3"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1957.tb12088.x"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1959.tb13331.x"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(80)90842-2"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(78)90504-8"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.18.2.178"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(88)90051-4"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-044276-8.50013-8"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1980.60.4.1167"},{"key":"e_1_2_1_13_1","first-page":"155","volume-title":"Neuronal Plasticity","author":"Grafstein B.","year":"1978"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1969.tb08974.x"},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1523\/JNEUROSCI.09-03-00893.1989","article-title":"Expression of GAP\u201043, a rapidly transported growth\u2010associated protein, and class II beta tubulin, a slowly transported cytoskeleton protein, are coordinated in regenerating neurons","volume":"9","author":"Hoffman P. 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