{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T10:16:24Z","timestamp":1789812984535,"version":"4.0.1"},"reference-count":42,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2004,10,11]],"date-time":"2004-10-11T00:00:00Z","timestamp":1097452800000},"content-version":"vor","delay-in-days":4120,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurobiol."],"published-print":{"date-parts":[[1993,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Peripheral nerve injury results in the increased synthesis and axonal trasnport of the growth\u2010associated protein GAP\u201043 in dorsal root ganglion (DRG) neurons, coincident with regenerative growth of the injured peripheral axon branches. To determine wheter the injury\u2010associated signalling mechanism which leads to GAP\u201043 induction also operates through the central branches of DRG axons, we used immunocytochemistry to compare the expression of GAP\u201043 in adult rat DRG neurons 2 weeks after dorsal root crush lesions (central axotomy) or peripheral nerve crush lesions (peripheral axotomy). In uninjured ganglia, a subpopulation of smaller DRG neurons expresses moderate levels of GAP\u201043, whereas larger neurons generally do not. At 2 weeks following peripheral axotomy, virtually all axotomized neurons, large and small, express high levels of GAP\u201043. At 2 weeks following dorsal root lesions, no increase in GAP\u201043 expression is detected. Thus, the injury\u2010associated up\u2010regulation of GAP\u201043 expression in DRG neurons is triggered by a mechanism that is responsive to injury of only the peripheral, and not the central, axon branches. These findings support the hypothesis that GAP\u201043 induction in DRG neurons is caused by disconnection from peripheral target tissue, not by axon injury per se. \u00a9 1993 John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/neu.480240709","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T03:24:23Z","timestamp":1104549863000},"page":"959-970","source":"Crossref","is-referenced-by-count":108,"title":["Injury\u2010associated induction of GAP\u201043 expression displays axon branch specificity in rat dorsal root ganglion neurons"],"prefix":"10.1002","volume":"24","author":[{"given":"David J.","family":"Schreyer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. H. 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