{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T19:20:07Z","timestamp":1700421607270},"reference-count":38,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2004,10,11]],"date-time":"2004-10-11T00:00:00Z","timestamp":1097452800000},"content-version":"vor","delay-in-days":4058,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurobiol."],"published-print":{"date-parts":[[1993,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Partial deafferentation of the olfactory bulb in <jats:italic>Xenopus<\/jats:italic> embryos was performed to analyze the effects of afferent innervation on the development of the central olfactory structure. In an attempt to analyze a possible early inductive role of the olfactory axons, one olfactory placode was removed before differentiation of the neural tube began (stages 26\u201331). A morphological and quantitative analysis was performed on larvae at the onset of metamorphic climax (stage 58). When the single olfactory nerve innervated one side of the rostral telencephalon, a single olfactory bulb developed on that side and no olfactory bulb formed on the contralateral side. When the nerve innervated the midline of the rostral telencephalon, a smaller\u2010than\u2010normal, fused olfactory bulb developed. Partial deafferentation at these early stages resulted in a significant reduction in the number of olfactory axons (to approximately one\u2010half of control values) and a corresponding decrease in the number of mitral\/tufted cells (output neurons of the olfactory bulb). To control for possible damage to the neural tube during olfactory\u2010placode removal, a portion of the neural tube directly beneath one of the olfactory placodes was removed in embryos. In these animals, the neural tube regenerated within 24 h and formed a normal olfactory bulb; olfactory axon and mitral\/tufted\u2010cell numbers were not significantly different from controls. In conclusion, olfactory\u2010afferent innervation was critical for differentiation of the olfactory bulb, and decreasing the number of olfactory axons resulted in a reduction in the number of output neurons of the olfactory bulb. \u00a9 1993 John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/neu.480240909","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T03:26:55Z","timestamp":1104550015000},"page":"1229-1242","source":"Crossref","is-referenced-by-count":35,"title":["The quantitative relationship between olfactory axons and mitral\/tufted cells in developing <i>Xenopus<\/i> with partially deafferented olfactory bulbs"],"prefix":"10.1002","volume":"24","author":[{"given":"Christine A.","family":"Byrd","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gail D.","family":"Burd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902310403"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903040109"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.900260203"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903140108"},{"key":"e_1_2_1_6_1","first-page":"230","article-title":"Mitral\/tufted cell and olfactory axon numbers are correlated in normal and partially deafferented Xenopus tadpoles","volume":"17","author":"Byrd C. 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