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Using ribonuclease protection analyses, we found an up\u2010regulation of V120 (containing the \u03b1<jats:sub>4<\/jats:sub>\u03b2<jats:sub>1<\/jats:sub> integrin binding site), as well as EIIIA, and EIIIB in fibronectin mRNAs in the crush\u2010injured adult rat sciatic nerve. <jats:italic>In situ<\/jats:italic> hybridization using splice variant\u2010specific probes revealed that cells within endoneurial tubes of the injured nerve synthesize these embryonic forms of fibronectin. Our results suggest that embryonic fibronectins synthesized within the nerve contribute to the permissiveness of the peripheral nervous system to axon regrowth and a mechanism by which alternative splicing of the V region in fibronectin mRNA could enhance nervous system regeneration. \u00a9 1995 John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/neu.480260203","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T03:48:45Z","timestamp":1104551325000},"page":"171-188","source":"Crossref","is-referenced-by-count":28,"title":["Embryonic fibronectins are up\u2010regulated following peripheral nerve injury in rats"],"prefix":"10.1002","volume":"26","author":[{"given":"Greta A.","family":"Mathews","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Ffrench\u2010Constant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01246356"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/296150a0"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.06-05-01241.1986"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(87)90021-2"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.106.3.857"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/365253a0"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6171034"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1988.tb03119.x"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.13.030190.000355"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.104.3.369"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.106.2.375"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.109.2.903"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(92)90168-D"},{"key":"e_1_2_1_15_1","first-page":"361","volume-title":"Peripheral Neuropathy","author":"Griffin J. 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