{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T20:18:42Z","timestamp":1790972322693,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,11]],"date-time":"2004-10-11T00:00:00Z","timestamp":1097452800000},"content-version":"vor","delay-in-days":3512,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurobiol."],"published-print":{"date-parts":[[1995,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A form of long\u2010term potentiation (LTP) is induced at the mossy fiber (MF) synapse in the hippocampus by highfrequency presynaptic stimulation (HFS). It is generally accepted that induction of this form of LTP (MF LTP) does not depend on postsynaptic Ca<jats:sup>2+<\/jats:sup> current gated by <jats:italic>N<\/jats:italic>\u2010methyl\u2010<jats:sc>D<\/jats:sc>\u2010aspartate receptors, but it has remained controversial whether induction depends on postsynaptic depolarization and voltage\u2010gated entry of Ca<jats:sup>2+<\/jats:sup>. There are also contradictory data on the time course of both LTP and post\u2010tetanic potentiation (PTP), a shorter duration form of potentiation observed at MF synapses immediately following HFS. It has been proposed that some of these differences in results may have arisen because of difficulties in isolating monosynaptic responses to MF input. In the present study, whole cell recording was used to observe excitatory postsynaptic currents (EPSCs) elicited in CA3 pyramidal cells by input from MFs. Postsynaptic cells were dialyzed with 1,2\u2010bis(o\u2010aminophenoxy)\u2010ethane\u2010N,N,N\u2032,N\u2032\u2010tetraacetic acid (BAPTA) and F<jats:sup>\u2212<\/jats:sup> to inhibit postsynaptic mechanisms that required Ca<jats:sup>2+<\/jats:sup>, cells were under voltage clamp during HFS, and conditions were selected to minimize the likelihood of polysynaptic contamination. Under these conditions, HFS nevertheless induced robust LTP (mean magnitude, 62%). The possibility that EPSCs were contaminated by polysynaptic components was investigated by exposing the slices to a suppressing medium (one that partially blocked neurotransmission). EPSC waveforms did not change shape during suppression, indicating that contamination was absent. The LTP observed always was accompanied by prominent PTP that lasted through the first 5 to 15 min following HFS (mean decay time constant, 3.2 min). Induction of this LTP was not cooperative; there was no relationship between the size of responses and the magnitude of the LTP induced. LTP magnitude also was unrelated to the extent to which postsynaptic cells depolarized during HFS. These results show that high rates of presynaptic MF activity elicit robust LTP whether or not there is accompanying postsynaptic depolarization or increase in the concentration of postsynaptic Ca<jats:sup>2+<\/jats:sup>. High\u2010frequency MF activity also results in a PTP that is unusually large and long. \u00a9 1995 John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/neu.480260309","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T03:49:00Z","timestamp":1104551340000},"page":"370-385","source":"Crossref","is-referenced-by-count":48,"title":["Posttetanic potentiation and presynaptically induced long\u2010term potentiation at the mossy fiber synapse in rat hippocampus"],"prefix":"10.1002","volume":"26","author":[{"given":"Ronald B.","family":"Langdon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon W.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"German","family":"Barrionuevo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(76)90858-1"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.8.2518"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1152\/jn.1986.55.3.540","article-title":"Conductance mechanism responsible for long\u2010term potentiation on monosynaptic and isolated excitatory synaptic inputs to hippocampus","volume":"55","author":"Barrionuevo G.","year":"1986","journal-title":"J. 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