{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T15:56:42Z","timestamp":1781798202184,"version":"3.54.5"},"reference-count":71,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,10,11]],"date-time":"2004-10-11T00:00:00Z","timestamp":1097452800000},"content-version":"vor","delay-in-days":3420,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurobiol."],"published-print":{"date-parts":[[1995,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Following peripheral nerve transection, a series of biochemical changes occurs in axons and Schwann cells both at the site of lesion and distal to it. Macrophages differentiated from monocytes that invade the area in response to transection (elicited macrophages) and, perhaps, also macrophages normally present in the tissue (resident macrophages) play important roles in these changes. In addition, nerve transection produces changes in the cell bodies of axotomized neurons and their surrounding glial cells, located at some distance from the lesion. To determine whether macrophages might play a role in the changes occurring in the superior cervical ganglion (SCG) after axotomy, we examined the presence of macrophages before and after axonal damage. The monoclonal antibodies ED1, ED2, and OX6 were used, each of which recognizes a somewhat different population of macrophages. Ganglia from normal rats contained a population of resident cells that were ED2+ but very few that were ED1+. Within 2 days after the postganglionic nerves were transected, the number of ED1+ cells increased substantially, with little change in immunostaining for ED2. These data, in combination with published studies on other tissues, suggest that ED1 in the SCG is selective for elicited macrophages and ED2 for resident macrophages. OX6 immunostaining was prominent in normal ganglia but also increased significantly after axotomy, suggesting that it reflects both macrophage populations. Systemic administration of 6\u2010hydroxydopamine, a neurotoxin that causes the destruction of sympathetic nerve endings, also produced an increase in ED1 immunostaining. Thus, the change in ED1 immunostaining in the SCG does not require surgery, with the attendant servering of local blood vessels and connective tissue, but rather only the disconnection of sympathetic neurons from their end organs. The time course of the invasion of monocytes after axotomy indicates that this process is not required to trigger the biochemical changes occurring in the ganglion within the first 24 h. On the other hand, the existence of a resident population of macrophages raises the possibility that changes in those cells might be involved. \u00a9 1995 John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/neu.480270203","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T03:51:27Z","timestamp":1104551487000},"page":"141-153","source":"Crossref","is-referenced-by-count":41,"title":["Changes in the macrophage population of the rat superior cervical ganglion after postganglionic nerve injury"],"prefix":"10.1002","volume":"27","author":[{"given":"R. C.","family":"Schreiber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. M.","family":"Shadiack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. A.","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. E.","family":"Sedwick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. E.","family":"Zigmond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,11]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"75","volume-title":"The Macrophage","author":"Adams D. O.","year":"1992"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.20.9302"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(92)90208-3"},{"key":"e_1_2_1_5_1","first-page":"1","volume-title":"The Macrophage","author":"Auger M. J.","year":"1992"},{"key":"e_1_2_1_6_1","first-page":"624","article-title":"Postganglionic axotomy and 6\u2010hydroxydopamine (6\u2010HDA) produce a burst of satellite cell proliferation in adult rat superior cervical ganglion (SCG)","volume":"18","author":"Bachoo M.","year":"1992","journal-title":"Soc. Neurosci. Abstr."},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.15.7109"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0171-2985(11)80586-3"},{"key":"e_1_2_1_9_1","first-page":"727","article-title":"Different reticular elements in rat lymphoid tissue identified by localization of Ia, Thy\u20101 and MRC OX 2 antigens","volume":"44","author":"Barclay A. N.","year":"1981","journal-title":"Immunology"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(91)90094-N"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01191706"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01148493"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00221931"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00325030"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(91)90245-U"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01206661"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00236252"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90163-5"},{"key":"e_1_2_1_19_1","first-page":"589","article-title":"The heterogeneity of mononuclear phagocytes in lymphoid organs: distinct macrophage subpopulations in the rat recognized by monoclonal antibodies ED1, ED2, and ED3","volume":"54","author":"Dijkstra C. D.","year":"1985","journal-title":"Immunology"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(89)90050-7"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1987.tb00534.x"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(93)90086-E"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.21.10440"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-73855-5_6"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(88)90585-X"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199311000-00001"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(92)90129-9"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490290315"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1401110308"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490290303"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(93)90267-3"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0889-1591(88)90029-3"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(76)90098-6"},{"key":"e_1_2_1_34_1","first-page":"415","volume-title":"Development, Regeneration and Plasticity of the Autonomic Nervous System","author":"Hendry I. A.","year":"1992"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.23.8735"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.13-04-01642.1993"},{"key":"e_1_2_1_37_1","first-page":"663","article-title":"Chemical sympathectomy with 6\u2010hydroxydopamine (6\u2010HDA) alters peptide expression in the superior cervical ganglion (SCG)","volume":"19","author":"Hyatt\u2010Sachs H.","year":"1993","journal-title":"Soc. Neurosci. Abstr."},{"key":"e_1_2_1_38_1","first-page":"258","volume-title":"Principles of Neural Science","author":"Jessell T. M.","year":"1991"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(93)90011-A"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830190128"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/330658a0"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01195557"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1975.sp010837"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1972.0040"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830090603"},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/neu.480250203"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01191724"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(91)90158-4"},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(69)90037-5"},{"key":"e_1_2_1_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00210032"},{"key":"e_1_2_1_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7696(08)61220-6"},{"key":"e_1_2_1_52_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.165.4.1218"},{"key":"e_1_2_1_53_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1975.sp011151"},{"key":"e_1_2_1_54_1","volume-title":"Degeneration and Regeneration of the Nervous System","author":"Ram\u00f3n y Cajal S.","year":"1928"},{"key":"e_1_2_1_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/neu.480240504"},{"key":"e_1_2_1_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(93)90229-K"},{"key":"e_1_2_1_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01795311"},{"key":"e_1_2_1_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(94)90200-3"},{"key":"e_1_2_1_59_1","first-page":"1499","article-title":"Changes in the macrophage population in the rat superior cervical ganglia (SCG) after axotomy","volume":"20","author":"Schreiber R. C.","year":"1994","journal-title":"Soc. Neurosci. Abstr."},{"key":"e_1_2_1_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(94)90180-5"},{"key":"e_1_2_1_61_1","doi-asserted-by":"crossref","unstructured":"Shadiack A. M. Vaccariello S. A. andZigmond R. E.(1995). Galanin expression in sympathetic ganglia after partial axotomy is highly localized to those neurons that are axotomized.Neuroscience(in press).","DOI":"10.1016\/0306-4522(95)00022-B"},{"key":"e_1_2_1_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091720311"},{"key":"e_1_2_1_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00687376"},{"key":"e_1_2_1_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(86)90519-7"},{"key":"e_1_2_1_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01187086"},{"key":"e_1_2_1_66_1","first-page":"664","article-title":"Differential effects of cholinergic differentiation factor\/leukemia inhibitory factor (CDF\/LIF) and NGF on peptide expression in adult rat superior cervical ganglion (SCG)","volume":"19","author":"Sun Y.","year":"1993","journal-title":"Soc. Neurosci. Abstr."},{"key":"e_1_2_1_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/neu.480250407"},{"key":"e_1_2_1_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00536990"},{"key":"e_1_2_1_69_1","first-page":"624","article-title":"Increases in glial fibrillary acidic protein (GFAP)\u2010like immunoreactivity (IR) in the superior cervical ganglion (SCG) after decentralization, axotomy and explanation","volume":"18","author":"Vaidyanathan U.","year":"1992","journal-title":"Soc. Neurosci. Abstr."},{"key":"e_1_2_1_70_1","first-page":"275","article-title":"Bone marrow\u2010derived elements in the peripheral nervous system. An immunohistochemical and ultrastructural investigation in chimeric rats","volume":"69","author":"Vass K.","year":"1993","journal-title":"Lab. Invest."},{"key":"e_1_2_1_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830161214"},{"key":"e_1_2_1_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.46.3.263"}],"container-title":["Journal of Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fneu.480270203","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/neu.480270203","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T14:59:50Z","timestamp":1698332390000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/neu.480270203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,6]]},"references-count":71,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1995,6]]}},"alternative-id":["10.1002\/neu.480270203"],"URL":"https:\/\/doi.org\/10.1002\/neu.480270203","archive":["Portico"],"relation":{},"ISSN":["0022-3034","1097-4695"],"issn-type":[{"value":"0022-3034","type":"print"},{"value":"1097-4695","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,6]]}}}