{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:53:59Z","timestamp":1791413639059,"version":"4.3.3"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,11,6]],"date-time":"2022-11-06T00:00:00Z","timestamp":1667692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nursing Open"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To systematically evaluate the efficacy of different topical treatments for PVC\u2010related phlebitis in hospital in\u2010patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A systematic review and meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A selection was made of experimental and quasi\u2010experimental studies published in English or Spanish. These should provide data on the degree of phlebitis, pain and infiltration (means and standard deviations, mainly) of hospitalized patients with phlebitis secondary to peripheral venous catheter. All those studies that reflected systemic or exclusive prevention treatments were excluded. Searches were from inception to April 2020. The date of data collection was from December 2020 to May 2021. The selection criteria were based on the PICOS model. Risk of bias was assessed using the Cochrane Collaboration tool.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twelve studies (726 patients) met the inclusion criteria. With respect to the decrease in the degree of phlebitis, was found ichthammol glycerine, followed by heparinoids. As for degree of pain, sesame oil obtained the most marked reduction. In terms of degree of infiltration, heparinoids and ichthammol glycerine were the only products to achieve a statistically significant reduction. The most important limitations are the low quantity and quality of the trials included. Insufficient data are available to draw valid conclusions about the efficacy of any treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nop2.1449","type":"journal-article","created":{"date-parts":[[2022,11,6]],"date-time":"2022-11-06T15:10:28Z","timestamp":1667747428000},"page":"1270-1280","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Peripheral venous <scp>catheter\u2010related<\/scp> phlebitis: A meta\u2010analysis of topical treatment"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6803-3333","authenticated-orcid":false,"given":"Judith","family":"Garcia\u2010Exp\u00f3sito","sequence":"first","affiliation":[{"name":"Department of Nursing and Physiotherapy, Faculty of Nursing and Physiotherapy University of Lleida  Lleida Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8412-788X","authenticated-orcid":false,"given":"Julio","family":"S\u00e1nchez\u2010Meca","sequence":"additional","affiliation":[{"name":"Meta\u2010Analysis Unit, Department of Basic Psychology and Methodology University of Murcia  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1060-3038","authenticated-orcid":false,"given":"Jos\u00e9 Alberto","family":"Almenta\u2010Saavedra","sequence":"additional","affiliation":[{"name":"Surgical Area, Hospital Cl\u00ednic Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7847-4252","authenticated-orcid":false,"given":"Laia","family":"Llubes\u2010Arri\u00e0","sequence":"additional","affiliation":[{"name":"Doctoral School University of Lleida  Lleida Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8072-1953","authenticated-orcid":false,"given":"Alba","family":"Torn\u00e9\u2010Ruiz","sequence":"additional","affiliation":[{"name":"Department of Nursing and Physiotherapy, Faculty of Nursing and Physiotherapy University of Lleida  Lleida Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0645-1668","authenticated-orcid":false,"given":"Judith","family":"Roca","sequence":"additional","affiliation":[{"name":"Department of Nursing and Physiotherapy, Faculty of Nursing and Physiotherapy University of Lleida  Lleida Spain"},{"name":"Health Care Research Group (GRECS) Biomedical Research Institute of Lleida  Lleida Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.4236\/mri.2019.84004"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.37591\/RRJOS.V5I1.1443"},{"issue":"11","key":"e_1_2_11_4_1","first-page":"142","article-title":"Comparison of efficacy, safety and pharmaco\u2010economic evaluation of \u201cichthammol glycerine\u201d, \u201cheparinoid preparation\u201d and \u201cmagnesium sulphate glycerine\u201d application on the reduction of post cannulation phlebitis: A randomized observer blind clinical study","volume":"5","author":"Basu B.","year":"2017","journal-title":"Global Scientific Journals"},{"issue":"2","key":"e_1_2_11_5_1","first-page":"92","article-title":"Treatment of superficial thrombophlebitis. 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P. T ThomasJ. ChandlerJ. CumpstonM. LiT. PageM. J. &WelchV. A.(2019).Cochrane Handbook for Systematic Reviews of Interventions version 6.0 (updated July 2019). Cochrane 2019.Handbook."},{"issue":"1","key":"e_1_2_11_16_1","first-page":"21","article-title":"Comparing the effect of warm moist compress and calendula ointment on the severity of phlebitis caused by 50% dextrose infusion: A clinical trial","volume":"6","author":"Jourabloo N.","year":"2017","journal-title":"Medical\u2010Surgical Nursing Journal"},{"key":"e_1_2_11_17_1","volume-title":"Effectiveness of topical application of fresh aloevera versus glycerine magnesium sulphate on children with phlebitis at government Rajaji hospital, Madurai","author":"Lalithambigai 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