{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:16:50Z","timestamp":1788999410222,"version":"build-2803163510"},"reference-count":61,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nursing Open"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Patients repeatedly experiencing a <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.collinsdictionary.com\/zh\/dictionary\/english-thesaurus\/sustained\">sustained<\/jats:ext-link> disease course, recurrent chronic pain, and serious sleep disorder will weaken their physical resistance and self\u2010care ability. Further evidence on patients with knee osteoarthritis (KOA) and related latent classes (LCs) of symptom clusters is needed in order to clarify its significance for symptom management and quality of life (QoL) enhancement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>This study aimed to generate evidence on differences in symptoms experienced by patients with knee osteoarthritis, identify related LCs, and explore the differences of each LC by demographic, disease, individual characteristics, and QoL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A convenience sample of 230 participants with knee osteoarthritis was surveyed. Sociodemographic and symptom questionnaires were collected. The analysis focused on the influencing factors that are associated with LC, intergroup differences, and associated QoL impacts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 230 participants with knee osteoarthritis completed the survey, average age was 64.54\u2009\u00b1\u20097.59. Three LCs were associated with knee osteoarthritis: LC1 (low symptom class), LC2 (high psychological disorder class) and LC3 (high fatigue with sleep disorder class), accounting for 56%, 24% and 20% respectively. Compared to LC1, LC2 was related to poor economic status, higher imaging grade and lower self\u2010efficacy. Notably, being older, being less educated, higher occurrence of chronic diseases, experiencing negative life events and having lower self\u2010efficacy rose in LC3.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patient or Public Contribution<\/jats:title><jats:p>The study identified LCs according to pain, anxiety, depression, fatigue and sleep disorder symptoms among patients with KOA, providing a foundation for further determining whether the clusters vary over time or along disease and treatment trajectory and what their possible synergistic effects are on KOA and associated QoL.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nop2.70264","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T21:04:14Z","timestamp":1751576654000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["On Patient Quality of Life: Impacts of Knee Osteoarthritis on Pain, Anxiety, Depression, Fatigue and Sleep Disorders"],"prefix":"10.1002","volume":"12","author":[{"given":"Guang\u2010Zhao","family":"Li","sequence":"first","affiliation":[{"name":"Department of Nursing Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong\u2010Jian","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Nursing The First Affiliated Hospital of Shandong First Medical University &amp; Shandong Provincial Qianfoshan Hospital  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui Ping","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Nursing The First Affiliated Hospital of Shandong First Medical University &amp; Shandong Provincial Qianfoshan Hospital  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Juan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Nursing Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3644-1022","authenticated-orcid":false,"given":"Paulo","family":"Moreira","sequence":"additional","affiliation":[{"name":"International Healthcare Management Research &amp; Development Center The First Affiliated Hospital of Shandong First Medical University &amp; Shandong Provincial Qianfoshan Hospital  Jinan Shandong China"},{"name":"Atlantica Instituto Universitario Gestao Em Saude  Oeiras Portugal"},{"name":"School of Social Affairs, Henan Normal University  Xinxiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,3]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/wics.51"},{"key":"e_1_2_12_3_1","first-page":"1102","article-title":"Osteoarthritis and Sleep: The Johnston County Osteoarthritis Project","volume":"35","author":"Allen K. 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