{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T06:17:56Z","timestamp":1787811476015,"version":"build-2784847793"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nursing Open"],"published-print":{"date-parts":[[2026,8]]},"abstract":"ABSTRACT<\/jats:title>\n \n Aim<\/jats:title>\n To evaluate the efficacy of establishing a nurse\u2010coordinated and guideline\u2010driven care by advanced stroke nurses for acute ischemic stroke (AIS).<\/jats:p>\n <\/jats:sec>\n \n Background<\/jats:title>\n \n Specialised nursing care is usually not integrated enough to provide high quality of interdisciplinary care for patients with\n AIS<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n A prospective study with retrospective controls.<\/jats:p>\n <\/jats:sec>\n \n Method<\/jats:title>\n A total of 231 patients with AIS were prospectively enrolled to receive the nurse\u2010coordinated and guideline\u2010driven care for intravenous thrombolysis (prospective cohort). A retrospective cohort using propensity\u2010score matching at a 1:1 ratio retrieved reviews of 231 cases. The primary endpoint was early major improvement in the National Institute of Health Stroke Scale (NIHSS) scores at 24\u2009h after thrombolysis. Secondary outcome measures included treatment time of each link at different stages, functional independence, EuroQoL 5\u2010dimension three\u2010level scale (EQ\u20105D\u20103L) scores and adverse events.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The rate of early major improvement in NIHSS score was 57.19% and 42.0% in the prospective and retrospective cohorts with a rate ratio of 1.361 (95% CI: 1.127\u20131.643) indicating superiority (\n p<\/jats:italic>\n \u2009=\u20090.002). A higher rate of functional independence was observed in the prospective cohort as compared to controls (77.9% vs. 68.8%,\n p<\/jats:italic>\n \u2009=\u20090.035). The mean time from admission was 17.11\u2009\u00b1\u20099.64\u2009min for imaging, 21.75\u2009\u00b1\u20098.42\u2009min for femoral artery puncture and 51.43\u2009\u00b1\u20099.64\u2009min for thrombolysis in the prospective cohort, which were shorter than those in controls (all\n p<\/jats:italic>\n \u2009<\u20090.001). EQ\u20105D\u20103L scores were better in prospective cases than in controls within 90\u2009days after thrombolysis (all\n p<\/jats:italic>\n \u2009<\u20090.05). A lower incidence of symptomatic intracranial haemorrhage was observed in the prospective cohort, while no significant difference in mortality up to 90\u2009days was found between the two cohorts.\n <\/jats:p>\n <\/jats:sec>\n \n No Patient or Public Contribution<\/jats:title>\n Although patients and the public were not directly involved in the design or conduct of this study, the research findings provide critical evidence that nursing\u2010led, guideline\u2010driven coordination directly improves the efficacy and safety in the management of patients with AIS by ensuring timely reaction, consistent application of evidence\u2010based protocols and enhanced multidisciplinary teamwork.<\/jats:p>\n \n Trial Registration:<\/jats:bold>\n Chinese Clinical Trial Registry: ChiCTR2200056818\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/nop2.70714","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T07:02:02Z","timestamp":1786086122000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nurse\u2010Coordinated and Guideline\u2010Driven Care in Acute Ischemic Stroke: A Prospective Study With Retrospective Propensity\u2010Score Matched Controls"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6637-2524","authenticated-orcid":false,"given":"Guili","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Neurology Xuanwu Hospital Capital Medical University, National Medical Center for Neurological Diseases, National Clinical Research Center for Geriatric Diseases Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9658-0138","authenticated-orcid":false,"given":"Lan","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Neurology Xuanwu Hospital Capital Medical University, National Medical Center for Neurological Diseases, National Clinical Research Center for Geriatric Diseases Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8369-6324","authenticated-orcid":false,"given":"Jie","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology Xuanwu Hospital Capital Medical University, National Medical Center for Neurological Diseases, National Clinical Research Center for Geriatric Diseases Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4302-6046","authenticated-orcid":false,"given":"Hong","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Neurology Xuanwu Hospital Capital Medical University, National Medical Center for Neurological Diseases, National Clinical Research Center for Geriatric Diseases Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,7]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ane.13476"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/2396987321989865"},{"key":"e_1_2_13_4_1","volume-title":"StatPearls [Internet]","author":"Brunt B. A.","year":"2025"},{"issue":"2","key":"e_1_2_13_5_1","first-page":"S140","article-title":"Acute Ischemic Stroke: Management Approach","volume":"23","author":"Chugh C.","year":"2019","journal-title":"Indian Journal of Critical Care Medicine"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2014.07.013"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/17474930241308142"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000034919"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.0589"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2024.108216"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphys.2013.12.012"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/nop2.1101"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.12669\/pjms.41.3.11056"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/svn-2020-000378"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.3233\/RNN-201080"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2016.11.016"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.26867"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0b013e3181e7512b"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9482876"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000211"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-022-11414-2"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.893807"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.4103\/neurol-india.ni_1187_21"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.192362"},{"key":"e_1_2_13_25_1","volume-title":"StatPearls [Internet]","author":"Tadi P.","year":"2025"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvn.2016.07.001"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.1455"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.604249"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.027708"}],"container-title":["Nursing Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nop2.70714","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/nop2.70714","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nop2.70714","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T05:31:55Z","timestamp":1787808715000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nop2.70714"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":28,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/nop2.70714"],"URL":"https:\/\/doi.org\/10.1002\/nop2.70714","archive":["Portico"],"relation":{},"ISSN":["2054-1058","2054-1058"],"issn-type":[{"value":"2054-1058","type":"print"},{"value":"2054-1058","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2025-07-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70714"}}