{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:07:03Z","timestamp":1790672823743,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T00:00:00Z","timestamp":1788048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T00:00:00Z","timestamp":1788048000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nursing Open"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate the symptom burden associated with MPNs and its impact on patients' psychophysical well\u2010being and quality of life through a structured PROM\u2010based nurse\u2010led visit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Observational study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included MPN patients followed at the haematology outpatient clinic of a large university\u2010affiliated hospital in Italy. Data were collected from September 2024 to March 2025 on 102 patients who underwent a structured PROM\u2010based nurse\u2010led visit supported by a dedicated symptom diary.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Symptom burden was substantial (85% were symptomatic) across all disease subtypes, with fatigue emerging as the most prominent symptom, affecting 72% of patients and accompanied by marked psychological distress (42% and 44% with anxious and depressive symptoms, respectively). Overall health\u2010related quality of life was predominantly moderate (mean score: 70.7\u2009\u00b1\u200921.3). Nearly all moderate\u2010to\u2010severe symptoms, including fatigue, inactivity, pain, itching, and abdominal discomfort, were strongly associated with impaired global health. 43% of patients need support in becoming more proactive in managing their disease, and satisfaction with the visit was very high (mean score 9.3\u2009\u00b1\u20091.3\/10).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The impact of MPNs was significant and multifaceted, affecting patients' physical, emotional, and social well\u2010being. Structured PROM\u2010based nurse\u2010led visits play a key role in detecting patients' needs and supporting symptom management across all domains of well\u2010being, fostering motivated engagement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Implications for the Profession and Patient Care<\/jats:title>\n                    <jats:p>Integrating structured PROM\u2010based nurse\u2010led visits into routine haematology care may improve symptom monitoring, support patient engagement, and guide timely and tailored supportive interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Impact<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Patients with MPNs experience a substantial physical and psychosocial symptom burden.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Symptom clusters are associated with anxiety, depression, and reduced quality of life.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Structured PROM\u2010based nurse\u2010led visits may facilitate the early identification of unmet supportive care needs.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Reporting Method<\/jats:title>\n                    <jats:p>Guidelines for reporting observational studies (STROBE):<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patient Contribution<\/jats:title>\n                    <jats:p>Patients actively participated during the nurse\u2010led visit and in data collection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nop2.70784","type":"journal-article","created":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T19:43:52Z","timestamp":1788119032000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nurse\u2010Led Patient\u2010Reported Outcome Assessment of Symptom Burden and Quality of Life in Myeloproliferative Neoplasms: An Observational Study"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9446-8864","authenticated-orcid":false,"given":"Daniela","family":"Berardinelli","sequence":"first","affiliation":[{"name":"Department of Public Health and Pediatrics University of Torino  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4896-981X","authenticated-orcid":false,"given":"Carmen","family":"Fava","sequence":"additional","affiliation":[{"name":"Department of Clinical and Biological Sciences University of Torino  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6491-8337","authenticated-orcid":false,"given":"Valentina","family":"Bonuomo","sequence":"additional","affiliation":[{"name":"Department of Clinical and Biological Sciences University of Torino  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selene","family":"Grano","sequence":"additional","affiliation":[{"name":"Department of Clinical and Biological Sciences University of Torino  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Sinisi","sequence":"additional","affiliation":[{"name":"Department of Public Health and Pediatrics University of Torino  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inga","family":"Ventimiglia","sequence":"additional","affiliation":[{"name":"AO Ordine Mauriziano Hospital  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graziella","family":"Costamagna","sequence":"additional","affiliation":[{"name":"AO Ordine Mauriziano Hospital  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1500-8692","authenticated-orcid":false,"given":"Paola","family":"Di Giulio","sequence":"additional","affiliation":[{"name":"Department of Public Health and Pediatrics University of Torino  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2722-1818","authenticated-orcid":false,"given":"Sara","family":"Campagna","sequence":"additional","affiliation":[{"name":"Department of Public Health and Pediatrics University of Torino  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1773-1072","authenticated-orcid":false,"given":"Andrea","family":"Ricotti","sequence":"additional","affiliation":[{"name":"AO Ordine Mauriziano Hospital  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0003-3481","authenticated-orcid":false,"given":"Valerio","family":"Dimonte","sequence":"additional","affiliation":[{"name":"Department of Public Health and Pediatrics University of Torino  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,30]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010022\u201007530\u20104"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010024\u201002827\u20109"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/JMDH.S513597"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000529750"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12955\u2010024\u201002312\u20104"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/NCC.0000000000001042"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hem3.70274"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/16078454.2023.2280731"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.6338"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejon.2025.102855"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejon.2025.102807"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201000366\u2010y"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2024.05.020"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/NCC.0000000000000792"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.71333"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136\u2010021\u201002972\u20105"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010025\u201002524\u20107"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soncn.2023.151448"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/HS9.0000000000000966"},{"key":"e_1_2_13_21_1","unstructured":"NCCN.2026.\u2018Guidelines Version 1.2026 on Myeloproliferative Neoplasms.\u2019.https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/mpn.pdf."},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408\u2010025\u201001234\u20108"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2022.2113531"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocn.17003"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26751"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41687\u2010021\u201000373\u20103"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1017\/S2045796022000592"}],"container-title":["Nursing 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