{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:55:29Z","timestamp":1791572129968,"version":"4.3.4"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nursing Open"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To identify predictors of peripherally inserted central catheter (PICC)\u2010related catheter\u2010associated skin injury (CASI) and to develop and temporally validate a bedside prediction model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective single\u2010centre cohort study, 1309 adults who underwent PICC insertion from June 2022 to June 2023 formed the development cohort and 568 adults enrolled from July to September 2023 formed the temporally separated validation cohort. Participants underwent prospective weekly skin assessment until PICC removal or 6\u2009months. Candidate predictors were selected using LASSO regression with 10\u2010fold cross\u2010validation and the one\u2010standard\u2010error rule, followed by multivariable logistic regression. The final six\u2010predictor model was assessed using bootstrap internal validation, temporal validation, calibration and decision\u2010curve analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>PICC\u2010related CASI occurred in 116 of 1309 participants (8.86%) in the development cohort and 40 of 568 (7.04%) in the validation cohort. The final model included primary tumour diagnosis (OR 3.86, 95% CI 1.30\u201311.50), history of catheterization (OR 5.08, 95% CI 2.67\u20139.67), iodophor disinfectant use (OR 0.11, 95% CI 0.05\u20130.25), functional dressing use (OR 0.16, 95% CI 0.06\u20130.41), cytotoxic drug use (OR 4.03, 95% CI 1.70\u20139.55) and hormonal drug use (OR 2.17, 95% CI 1.09\u20134.35). The optimism\u2010corrected AUC was 0.811 in the development cohort. In temporal validation, the AUC was 0.681 (95% CI 0.610\u20130.743).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The six\u2010predictor model demonstrated good discrimination in the development cohort and may assist clinicians in identifying patients at high risk of PICC\u2010related CASI. However, as a development\u2010stage prediction model, it requires recalibration and independent multicentre external validation before being considered for routine clinical use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Implications for Nursing Practice<\/jats:title>\n                    <jats:p>The identified predictors may help nurses recognize patients at higher risk of PICC\u2010related CASI and support more structured skin assessment during PICC care. As the model remains at the development stage, further recalibration and multicentre external validation are needed before routine clinical use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nop2.70895","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:36:16Z","timestamp":1791570976000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Development and Temporal Validation of a Prediction Model for\n                    <scp>PICC<\/scp>\n                    \u2010Related Catheter\u2010Associated Skin Injury"],"prefix":"10.1002","volume":"13","author":[{"given":"Xianghong","family":"Jin","sequence":"first","affiliation":[{"name":"Nursing Department Sir Run Run Shaw Hospital, Zhejiang University School of Medicine  Zhejiang Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8838-4616","authenticated-orcid":false,"given":"Xiuzhu","family":"Cao","sequence":"additional","affiliation":[{"name":"Nursing Department Sir Run Run Shaw Hospital, Zhejiang University School of Medicine  Zhejiang Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yidan","family":"Chen","sequence":"additional","affiliation":[{"name":"Nursing Department Sir Run Run Shaw Hospital, Zhejiang University School of Medicine  Zhejiang Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4131-9144","authenticated-orcid":false,"given":"Linfang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Nursing Department Sir Run Run Shaw Hospital, Zhejiang University School of Medicine  Zhejiang Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"issue":"4","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"e173","DOI":"10.1016\/S1470-2045(14)71116-7","article-title":"Nomograms in Oncology: More Than Meets the Eye","volume":"16","author":"Balachandran V. 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