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The Trp\u2010degrading enzymes, <jats:styled-content style=\"fixed-case\">TDO<\/jats:styled-content>2 and indoleamine 2,3\u2010dioxygenase, are activated by stress and\/or inflammation. Dysregulation of Trp metabolism, which causes shifts in the balance between Kyn and serotonin (5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>) pathways, is associated with psychiatric and neurological disorders. In genetic studies, single\u2010nucleotide polymorphisms in the <jats:italic><jats:styled-content style=\"fixed-case\">TDO<\/jats:styled-content>2<\/jats:italic> gene were shown to be involved in psychiatric disorders, such as schizophrenia and depression. It has been reported that targeted deletion of the <jats:italic>Tdo2<\/jats:italic> gene in mice resulted in reduced anxiety\u2010like behavior, enhanced exploratory activity and cognitive performance, and increased levels of Trp and 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> in the hippocampus and midbrain. However, the effect of <jats:italic>Tdo2<\/jats:italic> gene deletion on behavioral phenotypes has not yet been investigated extensively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials &amp; Methods<\/jats:title><jats:p>We conducted tests to further examine the behavioral effects of knockout (<jats:styled-content style=\"fixed-case\">KO<\/jats:styled-content>) of <jats:italic>Tdo2<\/jats:italic> in mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Deletion of <jats:italic>Tdo2<\/jats:italic> resulted in seemingly lower anxiety\u2010like behavior, higher locomotor activity, and abnormal gait pattern in mice, though none of them reached study\u2010wide statistical significance. <jats:italic>Tdo2<\/jats:italic> deficiency had no significant effects on other behaviors, such as prepulse inhibition, and depression\u2010like and social behaviors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion and Conclusion<\/jats:title><jats:p>He lack of clear phenotypes in <jats:italic>Tdo2<\/jats:italic><jats:styled-content style=\"fixed-case\">KO<\/jats:styled-content> mice in this study might be due to the absence of stress and inflammatory conditions, which could induce expression of <jats:italic>Tdo2<\/jats:italic> m<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>. Further studies are necessary to elucidate the roles of <jats:italic>Tdo2<\/jats:italic> in behavioral phenotypes related to psychiatric disorders.<\/jats:p><\/jats:sec>","DOI":"10.1002\/npr2.12006","type":"journal-article","created":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T09:27:34Z","timestamp":1515576454000},"page":"52-60","source":"Crossref","is-referenced-by-count":22,"title":["Comprehensive behavioral analysis of tryptophan 2,3\u2010dioxygenase (<i>Tdo2<\/i>) knockout mice"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1047-6454","authenticated-orcid":false,"given":"Satoko","family":"Hattori","sequence":"first","affiliation":[{"name":"Division of Systems Medical Science Institute for Comprehensive Medical Science Fujita Health University Toyoake Aichi 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