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Of particular relevance to neuropsychopharmacology is the fact that the problem is due in part to misuse of pharmaceuticals and especially the illicit production of the powerful synthetic opioids, fentanyl, and carfentanil.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>The development and adoption of appropriate pharmacotherapies are of critical importance. We discuss specific options to deal effectively with both withdrawal from opioid dependence and substitution of clinically approved drugs in place of illicit substances.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hopefully, this crisis will reinvigorate both basic and clinical neuropsychopharmacological research leading to the develop new and more effective options for dealing with the many and varied elements of the current opioid crisis as described in the present commentary.<\/jats:p><\/jats:sec>","DOI":"10.1002\/npr2.12026","type":"journal-article","created":{"date-parts":[[2018,8,10]],"date-time":"2018-08-10T11:48:13Z","timestamp":1533901693000},"page":"100-104","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Utilizing resources of neuropsychopharmacology to address the opioid overdose crisis"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4077-5471","authenticated-orcid":false,"given":"Anthony G.","family":"Phillips","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of British Columbia Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6208-4364","authenticated-orcid":false,"given":"Michael R.","family":"Krausz","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of British Columbia Vancouver British Columbia Canada"},{"name":"Centre for Health Evaluation and Outcome Sciences St. Paul's Hospital Vancouver British Columbia Canada"},{"name":"School of Population and Public Health University of British Columbia Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,8,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1465-3362.2010.00271.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1507771"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2018.0217"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2017.304265"},{"key":"e_1_2_11_6_1","unstructured":"AhmadF RossenL SpencerM WarnerM SuttonP.Provisional drug overdose death counts [Internet]. 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