{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T03:32:06Z","timestamp":1772767926555,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,9]],"date-time":"2018-11-09T00:00:00Z","timestamp":1541721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropsychopharm Rep"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Although electroencephalogram (EEG) seizure duration and seizure threshold change during a course of electroconvulsive therapy, the mechanisms by which these factors influence heart rate during subsequent electroconvulsive therapy sessions are currently unclear. In the current study, we investigated changes in heart rate during electroconvulsive therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recorded electroencephalography and electrocardiography during electroconvulsive therapy in 12 patients with major depressive disorder. Baseline heart rate was defined as the mean heart rate in the 30\u00a0seconds prior to stimulus onset. The Time<jats:sub>Max<\/jats:sub>peak refers to the maximum heart rate after stimulus onset. Time<jats:sub>1\/2<\/jats:sub>points represent the time points at which the heart rate had decreased to a value midway between the baseline heart rate and the Time<jats:sub>Max<\/jats:sub>peak. We examined the relationships between EEG seizure duration, Time<jats:sub>Max<\/jats:sub>, and Time<jats:sub>1\/2<\/jats:sub>throughout the course of electroconvulsive therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Time<jats:sub>1\/2<\/jats:sub>decreased as the number of electroconvulsive sessions increased. Time<jats:sub>1\/2<\/jats:sub>was positively correlated with EEG seizure duration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The duration in which electroconvulsive therapy\u2010induced sympathetic nervous system activation returned halfway to baseline levels gradually shortened during the course of electroconvulsive therapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/npr2.12037","type":"journal-article","created":{"date-parts":[[2018,11,9]],"date-time":"2018-11-09T10:18:54Z","timestamp":1541758734000},"page":"2-9","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Changes in cardiac autonomic nervous system activity during a course of electroconvulsive therapy"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7957-1743","authenticated-orcid":false,"given":"Yoko","family":"Suzuki","sequence":"first","affiliation":[{"name":"World Premier International 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