{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:34:43Z","timestamp":1791920083920,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T00:00:00Z","timestamp":1558915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["17H04243"],"award-info":[{"award-number":["17H04243"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropsychopharm Rep"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Parkinson's disease (PD) is a chronic and progressive neurodegenerative disorder. Although diet may influence the development of PD, the precise mechanisms underlying relationship between diet and PD pathology are unknown. Here, we examined whether dietary intake of glucoraphanin (GF), the precursor of a natural antioxidant sulforaphane in cruciferous vegetables, can affect the reduction of dopamine transporter (DAT) in the mouse striatum after repeated administration of MPTP (1\u2010methyl\u20104\u2010phenyl\u20101,2,3,6\u2010tetrahydropyridine).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Normal food pellet or 0.1% GF food pellet was given into male mice for 28\u00a0days from 8\u2010week\u2010old. Subsequently, saline (5\u00a0mL\/kg\u00a0\u00d7\u00a03, 2\u2010hour interval) or MPTP (10\u00a0mg\/kg\u00a0\u00d7\u00a03, 2\u2010hour interval) was injected into mice. Immunohistochemistry of DAT in the striatum was performed 7\u00a0days after MPTP injection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Repeated injections of MPTP significantly decreased the density of DAT\u2010immunoreactivity in the mouse striatum. In contrast, dietary intake of 0.1% GF food pellet significantly protected against MPTP\u2010induced reduction of DAT\u2010immunoreactivity in the striatum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study suggests that dietary intake of GF food pellet could prevent MPTP\u2010induced dopaminergic neurotoxicity in the striatum of adult mice. Therefore, dietary intake of GF\u2010rich cruciferous vegetables may have beneficial effects on prevention for development of PD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/npr2.12060","type":"journal-article","created":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T15:34:12Z","timestamp":1558971252000},"page":"247-251","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Dietary intake of glucoraphanin prevents the reduction of dopamine transporter in the mouse striatum after repeated administration of MPTP"],"prefix":"10.1002","volume":"39","author":[{"given":"Yaoyu","family":"Pu","sequence":"first","affiliation":[{"name":"Division of Clinical Neuroscience Chiba University Center for Forensic Mental Health Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youge","family":"Qu","sequence":"additional","affiliation":[{"name":"Division of Clinical Neuroscience Chiba University Center for Forensic Mental Health Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijia","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Clinical Neuroscience Chiba University Center for Forensic Mental Health Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si\u2010ming","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Clinical Neuroscience Chiba University Center for Forensic Mental Health Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Clinical Neuroscience Chiba University Center for Forensic Mental Health Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Ushida","sequence":"additional","affiliation":[{"name":"Innovation Division Kagome Co., Ltd. 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