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For antipsychotic drugs, adequate dopamine D2 receptor occupancy (\u201ctherapeutic window\u201d) is reported to be from 65%\u201070% to 80% to achieve the antipsychotic effect without extrapyramidal symptoms. For antidepressants, the clinical threshold of serotonin transporter (5\u2010HTT) occupancy is reported to be 70%\u201080% although the relation between the side effect and 5\u2010HTT occupancy has not yet been established. Evaluation of norepinephrine transporter (NET) occupancy for antidepressant is ongoing as adequate PET radioligands for NET were developed recently. Measurement of the target occupancy has been a key element to evaluate the in vivo target engagement of the drugs. In order to evaluate new drug targets for disease conditions such as negative symptoms\/cognitive impairment of schizophrenia and treatment\u2010resistant depression, new PET radioligands need to be developed concurrently with the drug development.<\/jats:p>","DOI":"10.1002\/npr2.12084","type":"journal-article","created":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T14:49:51Z","timestamp":1590677391000},"page":"114-121","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["PET technology for drug development in psychiatry"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5569-1361","authenticated-orcid":false,"given":"Ryosuke","family":"Arakawa","sequence":"first","affiliation":[{"name":"Center for Psychiatry Research Department of Clinical Neuroscience Karolinska Institutet and Stockholm County Council Stockholm 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