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It was previously reported to be increased by chronic treatment of electroconvulsive seizure, a model of electroconvulsive therapy (ECT), in rat hippocampus. The aim of this study was to examine whether serum levels of TSP\u20101 are associated with depression and ECT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serum TSP\u20101 levels of major depressive disorder (MDD) patients (n\u00a0=\u00a036) and age\u2010 and gender\u2010matched healthy controls (n\u00a0=\u00a036) were measured by TSP\u20101 ELISA. MDD patients were diagnosed according to the <jats:italic>Diagnostics and Statistical Manual of Mental Disorders<\/jats:italic>\u2010IV\u2010TR and underwent ECT. MDD patients were also analyzed for serum TSP\u20101 levels pre\u2010 and post\u2010ECT. Evaluation of symptoms was obtained using the Hamilton Rating Scale for Depression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum TSP\u20101 levels showed significant decreases specific to female MDD patients. However, TSP\u20101 did not change pre\u2010 and post\u2010ECT, did not correlate with symptoms, nor was not affected by the dose of antidepressants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Serum TSP\u20101 is a possible female\u2010specific factor that reflects depressive trait, but not state.<\/jats:p><\/jats:sec>","DOI":"10.1002\/npr2.12088","type":"journal-article","created":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T18:13:36Z","timestamp":1574878416000},"page":"39-45","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Decreased serum levels of thrombospondin\u20101 in female depressed patients"],"prefix":"10.1002","volume":"40","author":[{"given":"Mami","family":"Okada\u2010Tsuchioka","sequence":"first","affiliation":[{"name":"Division of Psychiatry and Neuroscience Institute for Clinical Research National Hospital Organization Kure Medical Center and Chugoku Cancer 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