{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:49:58Z","timestamp":1773294598270,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002975","name":"Dainippon Sumitomo Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002975","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropsychopharm Rep"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To report the efficacy and safety of blonanserin in patients with schizophrenia compared with risperidone in a Japanese multicenter, randomized, double\u2010blind study based on post hoc sensitivity analysis in addition to the previous results reported by Miura and discuss the current approaches for schizophrenia treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Of 302 patients randomized, 156 received blonanserin (8\u201024\u00a0mg\/d) and 145 received risperidone (2\u20106\u00a0mg\/d) for 8\u00a0weeks. Efficacy variables included the Positive and Negative Syndrome Scale (PANSS) total score for the primary outcome, PANSS subscale, Brief Psychiatric Rating Scale (BPRS), and Clinical Global Impression\u2010Improvement (CGI\u2010I) for secondary outcomes. Safety variables included treatment\u2010emergent adverse events, Drug Induced Extrapyramidal Symptoms Scale scores, laboratory data, vital signs, electrocardiogram, etc<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Blonanserin was not inferior to risperidone in the change in PANSS total score at a non\u2010inferior margin of \u22127 (intergroup difference, \u22120.46; 95% CI, \u22124.40 to 3.48). Post hoc analyses wholly supported the primary result. No major difference was found in the changes in BPRS scores and the improvement rate on CGI\u2010I between the drugs. The incidence of adverse events was similar in the two drugs. Blonanserin was associated with a lower risk of prolactin increase, weight gain, and orthostatic hypotension compared with risperidone. However, blonanserin was associated with a higher incidence of akathisia and excitability compared with risperidone. Most of the adverse events were mild to moderate in severity with no specific events of predominant high severity in the both drugs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Blonanserin exerted the similar efficacy to risperidone in both positive and negative symptoms in schizophrenia with a lower risk of prolactin increase, weight gain, and orthostatic hypotension compared with risperidone. Blonanserin will serve as a favorable treatment option for schizophrenia in daily clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.1002\/npr2.12089","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T21:17:11Z","timestamp":1575321431000},"page":"63-72","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Blonanserin vs risperidone in Japanese patients with schizophrenia: A post hoc analysis of a phase 3, 8\u2010week, multicenter, double\u2010blind, randomized controlled study"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9501-9366","authenticated-orcid":false,"given":"Philip D.","family":"Harvey","sequence":"first","affiliation":[{"name":"Leonard M. Miller Professor of Psychiatry and Behavioral Sciences University of Miami, Miller School of Medicine Miami FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7699-9840","authenticated-orcid":false,"given":"Hiroshi","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Medical Affairs Sumitomo Dainippon Pharma Co., Ltd Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadanori","family":"Miura","sequence":"additional","affiliation":[{"name":"Kitasato University School of Medicine Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,12]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2012.10.011"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2017.16121358"},{"key":"e_1_2_13_4_1","volume-title":"Guideline for pharmacological therapy of schizophrenia","author":"Japanese Society of","year":"2015"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S43404"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/npr2.12057"},{"key":"e_1_2_13_7_1","first-page":"297","article-title":"Clinical evaluation of blonanserin for schizophrenia: a randomized controlled study comparing blonanserin with risperidone [in Japanese]","volume":"11","author":"Miura S","year":"2008","journal-title":"Jpn J Clin Psychopharmacol"},{"key":"e_1_2_13_8_1","volume-title":"The prevention and treatment of missing data in clinical trials","author":"National Research Council","year":"2010"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.151.6.825"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S14385"},{"key":"e_1_2_13_11_1","volume-title":"The Positive and Negative Syndrome Scale (PANSS): rating manual","author":"Kay S","year":"1987"},{"issue":"1","key":"e_1_2_13_12_1","first-page":"97","article-title":"The Brief Psychiatric Rating Scale (BPRS): Recent developments in ascertainment and scaling","volume":"24","author":"Overall JE","year":"1988","journal-title":"Psychopharmacol Bull"},{"key":"e_1_2_13_13_1","volume-title":"A second\u2010generation rating scale for antipsychotic\u2010induced extrapyramidal symptoms: Drug\u2010induced Extrapyramidal Symptoms Scale","author":"Inada T","year":"2009"},{"issue":"1","key":"e_1_2_13_14_1","first-page":"101","article-title":"Efficacy and safety of risperidone in the treatment of chronic schizophrenic patients","volume":"22","author":"Fujii Y","year":"1993","journal-title":"Jpn J Clin Psychiatry [in Japanese]"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v58n1205"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1819.2001.00882.x"},{"issue":"2","key":"e_1_2_13_17_1","first-page":"295","article-title":"Clinical evaluation of aripiprazole in schizophrenic patients: A comparative double\u2010blind study with haloperidol [in Japanese]","volume":"9","author":"Ishigooka J","year":"2006","journal-title":"Rinsho Seishin Yakuri [Jpn J Clin Psychopharmacol]"},{"issue":"2","key":"e_1_2_13_18_1","first-page":"221","article-title":"Efficacy of a new antipsychotic, risperidone, on schizophrenia [abstract in English]","volume":"21","author":"Murasaki M","year":"1993","journal-title":"Rinsho Hyoka [Clin Eval]"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.22.6.0451"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.9758\/cpn.2016.14.3.238"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12991-017-0166-y"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S113099"},{"issue":"1","key":"e_1_2_13_23_1","first-page":"135","article-title":"Long\u2010term clinical study of blonanserin for schizophrenia: a multicenter open study to determine safety and effectiveness in schizophrenic patients (Japan\u2010wide study) [abstract in English]","volume":"11","author":"Kinoshita T","year":"2008","journal-title":"Rinsho Seishin Yakuri [Jpn J Clin Psychopharmacol]"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-0574-0088"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2010.04.027"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphs.2015.01.007"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S157475"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbj053"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.33160\/yam.2018.06.001"}],"container-title":["Neuropsychopharmacology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/npr2.12089","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/npr2.12089","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/npr2.12089","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T17:46:39Z","timestamp":1694022399000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/npr2.12089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1002\/npr2.12089"],"URL":"https:\/\/doi.org\/10.1002\/npr2.12089","archive":["Portico"],"relation":{},"ISSN":["2574-173X","2574-173X"],"issn-type":[{"value":"2574-173X","type":"print"},{"value":"2574-173X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"2019-02-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}