{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T05:51:49Z","timestamp":1770961909032,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T00:00:00Z","timestamp":1589846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["17ak0101044h0402"],"award-info":[{"award-number":["17ak0101044h0402"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropsychopharm Rep"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The \u03b54 allele of apolipoprotein E gene (APOE) is a well\u2010known risk factor of late\u2010onset Alzheimer's disease. However, little is known why this variant confers a risk for Alzheimer's disease. The aim of this study was to examine the influence of the APOE genotype on cerebrospinal fluid (CSF) protein levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The present study performed a secondary analysis on our previously generated database to compare the CSF levels of 1128 proteins between APOE\u2010\u03b54 carriers (28 subjects) and noncarriers (104 subjects). All subjects were physically healthy Japanese individuals without dementia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CSF levels of apoE2, apoE3, and apoE4 were significantly higher (all nominal <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a010\u00a0\u00d7\u00a010<jats:sup>\u22125<\/jats:sup>, false discovery rate\u00a0&lt;\u00a00.001) and those of tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) were significantly lower (nominal <jats:italic>P<\/jats:italic>\u00a0=\u00a01.39\u00a0\u00d7\u00a010<jats:sup>\u22126<\/jats:sup>, false discovery rate\u00a0&lt;\u00a00.001) in APOE\u2010\u03b54 carriers than in noncarriers. No significant correlation was observed between the CSF levels of TNF\u2010\u03b1 and any of the apoE proteins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings indicate the possible roles of apoE and TNF\u2010\u03b1 in the pathogenesis of APOE\u2010\u03b54\u2010associated Alzheimer's disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/npr2.12110","type":"journal-article","created":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T12:07:01Z","timestamp":1589890021000},"page":"201-205","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Increased apolipoprotein E and decreased TNF\u2010\u03b1 in the cerebrospinal fluid of nondemented APOE\u2010\u03b54 carriers"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3450-7283","authenticated-orcid":false,"given":"Daimei","family":"Sasayama","sequence":"first","affiliation":[{"name":"Department of Mental Disorder Research National Center of Neurology and Psychiatry National Institute of Neuroscience Kodaira Japan"},{"name":"Department of Psychiatry Shinshu University School of Medicine Matsumoto Japan"},{"name":"Child and Adolescent Developmental Psychiatry Shinshu University School of Medicine Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kotaro","family":"Hattori","sequence":"additional","affiliation":[{"name":"Department of Mental Disorder Research National Center of Neurology and Psychiatry National Institute of Neuroscience Kodaira Japan"},{"name":"Medical Genome Center National Center of Neurology and Psychiatry Kodaira Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuuki","family":"Yokota","sequence":"additional","affiliation":[{"name":"Department of Mental Disorder Research National Center of Neurology and Psychiatry National Institute of Neuroscience Kodaira Japan"},{"name":"Medical Genome Center National Center of Neurology and Psychiatry Kodaira Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Matsumura","sequence":"additional","affiliation":[{"name":"Medical Genome Center National Center of Neurology and Psychiatry Kodaira Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiya","family":"Teraishi","sequence":"additional","affiliation":[{"name":"Department of Mental Disorder Research National Center of Neurology and Psychiatry National Institute of Neuroscience Kodaira Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumiko","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Medical Genome Center National Center of Neurology and Psychiatry Kodaira Japan"},{"name":"Department of Psychiatry National Center of Neurology and Psychiatry National Center Hospital Kodaira Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7209-3790","authenticated-orcid":false,"given":"Hiroshi","family":"Kunugi","sequence":"additional","affiliation":[{"name":"Department of Mental Disorder Research National Center of Neurology and Psychiatry National Institute of Neuroscience Kodaira Japan"},{"name":"Department of Psychiatry Teikyo University School of Medicine Itabashi\u2010ku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,5,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2010.4"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-017-0335-x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002423"},{"issue":"1","key":"e_1_2_10_5_1","first-page":"44","article-title":"Genome\u2010wide quantitative trait loci mapping of the human cerebrospinal fluid proteome","volume":"26","author":"Sasayama D","year":"2017","journal-title":"Hum Mol 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