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However, there is no prophylactic nutrition that can prevent the onset of neurodevelopmental disorders in offspring after MIA. The aim of this study was undertaken to examine whether dietary intake of glucoraphanin (GF: the precursor of a natural anti\u2010inflammatory compound sulforaphane) can prevent the onset of behavioral abnormalities in offspring after MIA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One percent of GF food pellet or normal food pellet was given into female mice during pregnancy and lactation (from E5 to P21). Saline (5\u00a0mL\/kg\/d) or poly(I:C) (5\u00a0mg\/kg\/d) was injected into pregnant mice from E12 to E17. Behavioral tests and immunohistochemistry of parvalbumin (PV) were performed in male offspring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Dietary intake of GF during pregnancy and lactation prevented cognitive deficits and social interaction deficits in the juvenile offspring after MIA. Furthermore, dietary intake of GF during pregnancy and lactation prevented cognitive deficits in the adult offspring after MIA. Moreover, dietary intake of GF prevented the reduction of PV immunoreactivity in the medial prefrontal cortex of adult offspring after MIA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These data suggest that dietary intake of GF during pregnancy and lactation could prevent behavioral abnormalities in offspring after MIA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/npr2.12112","type":"journal-article","created":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T10:25:09Z","timestamp":1590661509000},"page":"268-274","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Dietary intake of glucoraphanin during pregnancy and lactation prevents the behavioral abnormalities in the offspring after maternal immune activation"],"prefix":"10.1002","volume":"40","author":[{"given":"Yuko","family":"Fujita","sequence":"first","affiliation":[{"name":"Division of Clinical Neuroscience Chiba University Center for Forensic Mental Health Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuhiro","family":"Fujita","sequence":"additional","affiliation":[{"name":"Division of Clinical Neuroscience Chiba University Center for Forensic Mental Health Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamaki","family":"Ishima","sequence":"additional","affiliation":[{"name":"Division of Clinical Neuroscience Chiba University Center for Forensic Mental Health Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayumi","family":"Hirai","sequence":"additional","affiliation":[{"name":"Innovation Division Kagome Co., Ltd. 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