{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:43:52Z","timestamp":1789951432767,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T00:00:00Z","timestamp":1597795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP20dm0107119"],"award-info":[{"award-number":["JP20dm0107119"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropsychopharm Rep"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Depression is a common symptom in people with osteoporosis. (<jats:italic>R<\/jats:italic>)\u2010ketamine produced greater potency and longer\u2010lasting antidepressant\u2010like actions than (<jats:italic>S<\/jats:italic>)\u2010ketamine in rodents. Here, we examined the effects of two ketamine enantiomers on the reduced bone mineral density (BMD) in the ovariectomized (OVX) mice which is an animal model of postmenopausal osteoporosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Female ddY mice were OVX or sham\u2010operated. Subsequently, saline (10\u00a0mL\/kg\/d, twice weekly), (<jats:italic>R<\/jats:italic>)\u2010ketamine (10\u00a0mg\/kg\/d, twice weekly), or (<jats:italic>S<\/jats:italic>)\u2010ketamine (10\u00a0mg\/kg\/d, twice weekly) was administered intraperitoneally into OVX or sham mice for the 6\u00a0weeks. The femur from all mice was collected 3\u00a0days after the final injection, and BMD in the femur was measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The reduction of cortical BMD and total BMD in the OVX mice was significantly ameliorated after subsequent repeated intermittent administration of (<jats:italic>R<\/jats:italic>)\u2010ketamine, but not (<jats:italic>S<\/jats:italic>)\u2010ketamine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The study shows that (<jats:italic>R<\/jats:italic>)\u2010ketamine can ameliorate the reduced cortical BMD and total BMD in OVX mice. Therefore, (<jats:italic>R<\/jats:italic>)\u2010ketamine would be a novel therapeutic drug for women with osteoporosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/npr2.12132","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T06:14:22Z","timestamp":1598595262000},"page":"401-406","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Decreased bone mineral density in ovariectomized mice is ameliorated after subsequent repeated intermittent administration of (<i>R<\/i>)\u2010ketamine, but not (<i>S<\/i>)\u2010ketamine"],"prefix":"10.1002","volume":"40","author":[{"given":"Yuko","family":"Fujita","sequence":"first","affiliation":[{"name":"Division of Clinical Neuroscience Chiba University Center for Forensic Mental Health  Chiba 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