{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T18:22:44Z","timestamp":1766514164314,"version":"3.40.5"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,9,19]],"date-time":"2020-09-19T00:00:00Z","timestamp":1600473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropsychopharm Rep"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Clozapine use is complicated by an increased risk of hematological adverse effects such as neutropenia and, rarely, eosinophilia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>We present the case of a 48\u2010year\u2010old man with treatment\u2010resistant schizophrenia. On day 12 after clozapine initiation, he had a cough with a temperature of 39.8\u00b0C. On day 16, his leukocyte count had increased to 9320\u00a0cells\/mm<jats:sup>3<\/jats:sup> (neutrophils 7550\u00a0cells\/mm<jats:sup>3<\/jats:sup> and eosinophils 680\u00a0cells\/mm<jats:sup>3<\/jats:sup>). We discontinued lithium because of neutrophilia and damage to renal function on day 20. His eosinophil count increased until day 29, reaching 6750\u00a0cells\/mm<jats:sup>3<\/jats:sup>. We suspected a drug\u2010induced reaction and discontinued clozapine on day 30. His eosinophil count gradually decreased, reaching the normal range by day 40. However, his leukocyte and neutrophil counts also gradually decreased to below than the normal range by day 40. His leukocytes and neutrophil counts had recovered by day 55.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We concluded that this patient had clozapine\u2010associated severe eosinophilia following lithium rebound neutropenia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/npr2.12143","type":"journal-article","created":{"date-parts":[[2020,9,20]],"date-time":"2020-09-20T05:37:25Z","timestamp":1600580245000},"page":"388-391","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Clozapine\u2010associated severe eosinophilia following lithium rebound neutropenia: A case report"],"prefix":"10.1002","volume":"40","author":[{"given":"Kota","family":"Kikuchi","sequence":"first","affiliation":[{"name":"Department of Psychiatry School of Medicine Dokkyo Medical University  Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4414-3770","authenticated-orcid":false,"given":"Norio","family":"Yasui\u2010Furukori","sequence":"additional","affiliation":[{"name":"Department of Psychiatry School of Medicine Dokkyo Medical University  Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saaya","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Department of Psychiatry School of Medicine Dokkyo Medical University  Tochigi Japan"},{"name":"Department of Psychiatry Okamotodai Hospital  Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chie","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Psychiatry School of Medicine Dokkyo Medical University  Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuhiko","family":"Kokubun","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Generalist Medicine School of Medicine Dokkyo Medical University Hospital  Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Katsukura","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Generalist Medicine School of Medicine Dokkyo Medical University Hospital  Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taro","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Generalist Medicine School of Medicine Dokkyo Medical University Hospital  Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazutaka","family":"Shimoda","sequence":"additional","affiliation":[{"name":"Department of Psychiatry School of Medicine Dokkyo Medical University  Tochigi 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