{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:23:52Z","timestamp":1792027432538,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,2,21]],"date-time":"2021-02-21T00:00:00Z","timestamp":1613865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP18dm0207006"],"award-info":[{"award-number":["JP18dm0207006"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP20dm0207069"],"award-info":[{"award-number":["JP20dm0207069"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP20dm0307002"],"award-info":[{"award-number":["JP20dm0307002"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP20dm0307102"],"award-info":[{"award-number":["JP20dm0307102"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP20lm0203007"],"award-info":[{"award-number":["JP20lm0203007"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20H03611"],"award-info":[{"award-number":["20H03611"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K06920"],"award-info":[{"award-number":["20K06920"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP18dm0207006"],"award-info":[{"award-number":["JP18dm0207006"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP20dm0207069"],"award-info":[{"award-number":["JP20dm0207069"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP20dm0307002"],"award-info":[{"award-number":["JP20dm0307002"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP20dm0307102"],"award-info":[{"award-number":["JP20dm0307102"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP20lm0203007"],"award-info":[{"award-number":["JP20lm0203007"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K06920"],"award-info":[{"award-number":["20K06920"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20H03611"],"award-info":[{"award-number":["20H03611"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropsychopharm Rep"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Abnormal eye movements are often associated with psychiatric disorders. Eye movements are sensorimotor functions of the brain, and aging and sex would affect their characteristics. A precise understanding of normal eye movements is required to distinguish disease\u2010related abnormalities from natural differences associated with aging or sex. To date, there is no multicohort study examining age\u2010related dependency and sex effects of eye movements in healthy, normal individuals using large samples to ensure the robustness and reproducibility of the results. In this study, we aimed to provide findings showing the impact of age and sex on eye movement measures. The present study used eye movement measures of more than seven hundred healthy individuals from three large independent cohorts. We herein evaluated eye movement measures quantified by using a set of standard eye movement tests that have been utilized for the examination of patients with schizophrenia. We assessed the statistical significance of the effects of age and sex and its reproducibility across cohorts. We found that 4\u201018 out of 35 eye movement measures were significantly correlated with age, depending on the cohort, and that 10 of those, which are related to the fixation and motor control of smooth pursuit and saccades, showed high reproducibility. On the other hand, the effects of sex, if any, were less reproducible. The present results suggest that we should take age into account when we evaluate abnormalities in eye movements.<\/jats:p>","DOI":"10.1002\/npr2.12163","type":"journal-article","created":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T06:41:56Z","timestamp":1613976116000},"page":"152-158","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Effects of age and sex on eye movement characteristics"],"prefix":"10.1002","volume":"41","author":[{"given":"Junichi","family":"Takahashi","sequence":"first","affiliation":[{"name":"Department of Neuropsychiatry Graduate School of Medical Sciences Kyushu University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3722-7837","authenticated-orcid":false,"given":"Kenichiro","family":"Miura","sequence":"additional","affiliation":[{"name":"Department of Pathology of Mental Diseases National Institute of Mental Health National Center of Neurology and Psychiatry Kodaira Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Morita","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation University of Tokyo Hospital Tokyo Japan"},{"name":"Department of Neuropsychiatry University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiko","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Department of Pathology of Mental Diseases National Institute of Mental Health National Center of Neurology and Psychiatry Kodaira Japan"},{"name":"Department of Psychiatry Graduate School of Medicine Osaka University Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiko","family":"Miyata","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Graduate School of Medicine Nagoya University Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosuke","family":"Okazaki","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Nara Medical University Kashihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4228-3208","authenticated-orcid":false,"given":"Junya","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Pathology of Mental Diseases National Institute of Mental Health National Center of Neurology and Psychiatry Kodaira Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Pathology of Mental Diseases National Institute of Mental Health National Center of Neurology and Psychiatry Kodaira Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoji","family":"Hirano","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Graduate School of Medical Sciences Kyushu University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenaga","family":"Yamamori","sequence":"additional","affiliation":[{"name":"Department of Pathology of Mental Diseases National Institute of Mental Health National Center of Neurology and Psychiatry Kodaira Japan"},{"name":"Department of Psychiatry Graduate School of Medicine Osaka University Suita Japan"},{"name":"Japan Community Health Care Organization Osaka Hospital Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Pathology of Mental Diseases National Institute of Mental Health National Center of Neurology and Psychiatry Kodaira Japan"},{"name":"Medical Corporation Foster Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Makinodan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Nara Medical University Kashihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoto","family":"Kasai","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry University of Tokyo Tokyo Japan"},{"name":"The International Research Center for Neurointelligence (WPI\u2010IRCN) at University of Tokyo Institutes for Advanced Study (UTIAS) Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Ozaki","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Graduate School of Medicine Nagoya University Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Onitsuka","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Graduate School of Medical Sciences Kyushu University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5941-4238","authenticated-orcid":false,"given":"Ryota","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Pathology of Mental Diseases National Institute of Mental Health National Center of Neurology and Psychiatry Kodaira Japan"},{"name":"Department of Psychiatry Graduate School of Medicine Osaka University Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,21]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.12911"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2016.04.009"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.12474"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.04.019"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2014.10.023"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.12460"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3956(98)00019-3"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2014.12.020"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2017.04.027"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.12551"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.12934"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2018.03.017"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41537-018-0070-8"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.12852"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.12823"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2010.01.014"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.12865"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.12963"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-019-0553-7"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.05-1311"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/49.5.M235"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(98)00369-2"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2009.04.001"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6989(83)90038-X"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.3200\/JMBR.38.5.373-382"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2018.06.064"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2018.12.051"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000002864"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/med\/9780199969289.001.0001"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-001-0912-9"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00801.2003"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/31.3.451"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/19.3.461"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.181.4095.179"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(88)90050-9"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(90)90035-Z"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.090169"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/npr2.12087"}],"container-title":["Neuropsychopharmacology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/npr2.12163","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/npr2.12163","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/npr2.12163","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T07:37:31Z","timestamp":1693381051000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/npr2.12163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,21]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1002\/npr2.12163"],"URL":"https:\/\/doi.org\/10.1002\/npr2.12163","archive":["Portico"],"relation":{},"ISSN":["2574-173X","2574-173X"],"issn-type":[{"value":"2574-173X","type":"print"},{"value":"2574-173X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,21]]},"assertion":[{"value":"2020-07-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}