{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:50:54Z","timestamp":1786978254047,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,3,6]],"date-time":"2021-03-06T00:00:00Z","timestamp":1614988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007428","name":"Naito Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005927","name":"Daiichi Sankyo Foundation of Life Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005927","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropsychopharm Rep"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      Dietary Mg\n                      <jats:sup>2+<\/jats:sup>\n                      deficiency (MgD) impairs hippocampus\u2010dependent memory in mice; however, the molecular mechanisms underlying MgD\u2010induced memory impairments are unclear. Here, we investigated the molecular signatures in the hippocampus of MgD mice by analyzing the hippocampal transcriptome.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed RNA\u2010sequencing of the hippocampal transcriptome of MgD mice. We used gene ontology analyses and quantitative real\u2010time PCR to validate the RNA\u2010sequencing results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>mRNAs for neuroinflammation\u2010related genes were upregulated in the hippocampus and cortex of MgD mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MgD induces neuroinflammation in the mouse brain, including the hippocampus and cortex. Our findings suggest that MgD\u2010induced neuroinflammation triggers the impairments of hippocampus\u2010dependent memory.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/npr2.12167","type":"journal-article","created":{"date-parts":[[2021,3,6]],"date-time":"2021-03-06T04:54:06Z","timestamp":1615006446000},"page":"230-236","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Dietary magnesium deficiency induces the expression of neuroinflammation\u2010related genes in mouse brain"],"prefix":"10.1002","volume":"41","author":[{"given":"Ryuhei","family":"Tsuji","sequence":"first","affiliation":[{"name":"Department of Applied Biological Chemistry Graduate school of Agriculture and Life Sciences The University of Tokyo  Tokyo Japan"},{"name":"Faculty of Applied Bioscience Department of Bioscience Tokyo University of Agriculture  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Inoue","sequence":"additional","affiliation":[{"name":"Faculty of Applied Bioscience Department of Nutritional Science and Food Safety Tokyo University of Agriculture  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariko","family":"Uehara","sequence":"additional","affiliation":[{"name":"Faculty of Applied Bioscience Department of Nutritional Science and Food Safety Tokyo University of Agriculture  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8038-9583","authenticated-orcid":false,"given":"Satoshi","family":"Kida","sequence":"additional","affiliation":[{"name":"Department of Applied Biological Chemistry Graduate school of Agriculture and Life Sciences The University of Tokyo  Tokyo Japan"},{"name":"Faculty of Applied Bioscience Department of Bioscience Tokyo University of Agriculture  Tokyo 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