{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:30:33Z","timestamp":1777933833621,"version":"3.51.4"},"reference-count":6,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,3,21]],"date-time":"2021-03-21T00:00:00Z","timestamp":1616284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K08037"],"award-info":[{"award-number":["19K08037"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP19dm0908001"],"award-info":[{"award-number":["JP19dm0908001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropsychopharm Rep"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Multiple sleep latency test (MSLT) is performed as objective assessment of sleepiness, on the following day after polysomnography (PSG). In most clinics, patients are required to stay for 2\u00a0days. However, if patients have chronic sleep debt before the examination, even if they get adequate nocturnal sleep during the initial PSG, their sleep debt would not be fully resolved, affecting MSLT results. This may lead to improper administration of psycho\u2010stimulant medication. To clarify the sleep debt for the patients who showed short sleep latencies, we compared the mean sleep latencies of MSLTs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twelve hypersomnolent males, who underwent MSLTs (1st MSLT with 1 night and 2nd MSLT with more than 3 nights), were enrolled. We selected these cases based on the longer total sleep time on PSG night compared to the mean total sleep time on pre\u2010examination sleep logs and shortened sleep latencies on PSG. To evaluate the effect of the sleep debt for the patients who showed short sleep latencies, we extended their hospitalization or re\u2010hospitalized them.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean sleep latency of 1st MSLT was 5.8\u00a0minutes and that of 2nd was 13.9\u00a0minutes (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). Among these 12 cases, 5 cases altered from short to normal sleep latencies at the 2nd MSLT. These 5 cases were prevented from over\u2010diagnoses by the extension of evaluations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The sleep debt may produce false\u2010positive results when patients are examined by standard PSG and MSLT. Accumulation of sleep debt will cause shortened sleep latencies in the following nights. Patients should be advised to extend their hospitalization before PSG and MSLT to reduce the chronic sleep debt for accurate diagnosis of hypersomnia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/npr2.12169","type":"journal-article","created":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T06:58:48Z","timestamp":1616396328000},"page":"192-198","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["False\u2010positive cases in multiple sleep latency test by accumulated sleep debt"],"prefix":"10.1002","volume":"41","author":[{"given":"Tetsuya","family":"Kizawa","sequence":"first","affiliation":[{"name":"Division of Behavioral Sleep Medicine Iwate Medical University School of Medicine Morioka Japan"},{"name":"Neuropsychiatry Akita University School of Medicine Akita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Hosokawa","sequence":"additional","affiliation":[{"name":"Division of Behavioral Sleep Medicine Iwate Medical University School of Medicine Morioka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuguo","family":"Nishijima","sequence":"additional","affiliation":[{"name":"Division of Behavioral Sleep Medicine Iwate Medical University School of Medicine Morioka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Division of Behavioral Sleep Medicine Iwate Medical University School of Medicine Morioka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuo","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Neuropsychiatry Akita University School of Medicine Akita Japan"},{"name":"Akita Mental Health and Wellfare Center Akita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taisuke","family":"Ono","sequence":"additional","affiliation":[{"name":"Neuropsychiatry Akita University School of Medicine Akita Japan"},{"name":"Department of Psychiatry and Behavioral Sciences, Sleep and Circadian Neurobiology Laboratory Stanford University School of Medicine Standford CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GoEun","family":"Han","sequence":"additional","affiliation":[{"name":"International Institute for Integrative Sleep Medicine Tsukuba University Tsukuba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9205-007X","authenticated-orcid":false,"given":"Takashi","family":"Kanbayashi","sequence":"additional","affiliation":[{"name":"International Institute for Integrative Sleep Medicine Tsukuba University Tsukuba Japan"},{"name":"Ibaraki Prefectural Medical Center of Psychiatry Kasama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Sakurai","sequence":"additional","affiliation":[{"name":"Division of Behavioral Sleep Medicine Iwate Medical University School of Medicine Morioka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0856-6650","authenticated-orcid":false,"given":"Hideaki","family":"Kondo","sequence":"additional","affiliation":[{"name":"International Institute for Integrative Sleep Medicine Tsukuba University Tsukuba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1389-9457(02)00065-5"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.5664\/JCSM.1206"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.26972"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.2922"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s41105-017-0116-8"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.6882"}],"container-title":["Neuropsychopharmacology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/npr2.12169","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/npr2.12169","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/npr2.12169","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T07:37:19Z","timestamp":1693381039000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/npr2.12169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,21]]},"references-count":6,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1002\/npr2.12169"],"URL":"https:\/\/doi.org\/10.1002\/npr2.12169","archive":["Portico"],"relation":{},"ISSN":["2574-173X","2574-173X"],"issn-type":[{"value":"2574-173X","type":"print"},{"value":"2574-173X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,21]]},"assertion":[{"value":"2020-06-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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