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Therefore, we report the preliminary findings of the antinociceptive effects of the combined use of butorphanol and buprenorphine in C57BL\/6JJcl mice. Both drugs were administered either simultaneously or in different orders. Compared with the baseline values, the tail\u2010flick and hot\u2010plate test latencies increased regardless of the order of administration. Furthermore, enhanced latencies were observed on administration of butorphanol followed by buprenorphine. Combined use of these drugs may not attenuate analgesic efficacy. Besides, enhancement of these effects can be obtained by changing the order of the administration of these drugs. It is necessary to further investigate the molecular basis of the underlying mechanism in future definitive studies.<\/jats:p>","DOI":"10.1002\/npr2.12202","type":"journal-article","created":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T10:23:21Z","timestamp":1631269401000},"page":"522-525","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Antinociceptive effects of the combined use of butorphanol and buprenorphine in mice"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3895-9973","authenticated-orcid":false,"given":"Kazumasu","family":"Sasaki","sequence":"first","affiliation":[{"name":"Research Institute for Brain and Blood Vessels Akita Cerebrospinal and Cardiovascular Center Akita Japan"},{"name":"Addictive Substance Project Tokyo Metropolitan Institute of Medical Science Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Research Institute for Brain and Blood Vessels Akita Cerebrospinal and Cardiovascular Center Akita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8342-0278","authenticated-orcid":false,"given":"Kazutaka","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Addictive Substance Project Tokyo Metropolitan Institute of Medical Science Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9955-629X","authenticated-orcid":false,"given":"Shinya","family":"Kasai","sequence":"additional","affiliation":[{"name":"Addictive Substance Project Tokyo Metropolitan Institute of Medical Science Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,10]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpa.2020.06.003"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200505000-00021"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119421375.ch11"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-800036-6.00004-1"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000002718"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.68.7.699"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2008.03.008"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1258\/la.2012.010066"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000005017"},{"key":"e_1_2_13_11_1","first-page":"688","article-title":"Comparison of pharmacological activities of buprenorphine and norbuprenorphine: norbuprenorphine is a potent opioid agonist","volume":"297","author":"Huang P","year":"2001","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159043359477"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e318238fea0"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.112.194308"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.21914"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2005.02.002"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmr.2020.02.001"},{"key":"e_1_2_13_18_1","volume-title":"L. 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