{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:45:39Z","timestamp":1761129939870,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T00:00:00Z","timestamp":1634860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropsychopharm Rep"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Lithium carbonate is used to increase white blood cell counts as a means of counteracting leukopenia caused by the administration of antipsychotic drugs. To evaluate the effect of antipsychotics on the leukocyte\u2010enhancing effect of lithium, we compared white blood cell counts, serum lithium levels, and lithium dosage in patients receiving antipsychotics and lithium in combination and patients receiving lithium alone. Chlorpromazine equivalent values were used as an indicator of the antipsychotic dose.<\/jats:p><jats:p>Lithium serum levels were measured in 41 hospitalized patients. The lithium dose in the combination group (median, 800\u00a0mg) was significantly higher than that in group receiving only lithium (median, 400\u00a0mg) (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03). The lithium doses in the combination group receiving \u22651000\u00a0mg chlorpromazine equivalents (overdosing; median lithium dose 800\u00a0mg) and the combination group treated with 600\u2010999\u00a0mg chlorpromazine equivalents (high dosing; median lithium dose 800\u00a0mg) were significantly higher than the group that was not treated with antipsychotic medication, with median lithium dose 400\u00a0mg (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).There were no significant differences in the white blood cell counts and serum lithium levels.<\/jats:p><jats:p>Because of the large variety of antipsychotic drugs used in combination with lithium and the various doses used, it was difficult to evaluate the effects of lithium, with or without antipsychotic administration, on leukocyte count enhancement. We are planning to study a larger number of patients and, since renal function could not be assessed in this study, we will also focus on renal function, including urine output.<\/jats:p>","DOI":"10.1002\/npr2.12210","type":"journal-article","created":{"date-parts":[[2021,10,23]],"date-time":"2021-10-23T06:43:10Z","timestamp":1634971390000},"page":"532-537","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of antipsychotics on serum lithium levels and white blood cell counts"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1022-3569","authenticated-orcid":false,"given":"Ryo","family":"Obara","sequence":"first","affiliation":[{"name":"Department of Pharmacy Kawasaki Kokoro Hospital Miyagi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Tomita","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Faculty of Pharmaceutical Sciences Teikyo Heisei University Tokyo Japan"},{"name":"Department of Pharmacy Hospital Bando Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidekazu","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Hospital Bando Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukinao","family":"Kohda","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Hospital Bando Ibaraki Japan"},{"name":"Faculty of Health Sciences Tsukuba International University Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Internal Medicine Hospital Bando Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenzo","family":"Kudo","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Iwate Medical University Hospital Iwate Japan"},{"name":"Department of Clinical Pharmaceutics and Pharmacy Practice School of Pharmacy Iwate Medical University Iwate Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,22]]},"reference":[{"key":"e_1_2_13_2_1","unstructured":"Taisho Pharmaceutical Co. 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Package insert of LIMAS\u00aetab. 100 \/ tab. 200. 12th ed 2019."},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-016-0874-x"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/2045125315624063"},{"issue":"6","key":"e_1_2_13_5_1","article-title":"Olanzapine\u2010associated leukopenia and thrombocytopenia managed with lithium in a patient who developed leukopenia with clozapine in the past: a case report","volume":"14","author":"Grover S","year":"2012","journal-title":"Prim Care Companion CNS Disord"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-004-0835-z"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2011.0136"},{"volume-title":"Guideline for Pharmacological Therapy of Schizophrenia","year":"2017","author":"Japanese Society of Neuropsychopharmacology","key":"e_1_2_13_8_1"},{"issue":"3","key":"e_1_2_13_9_1","first-page":"215","article-title":"Lithium dosage and leukocyte counts in psychiatric patients","volume":"24","author":"Oyewumi LK","year":"1999","journal-title":"J Psychiatry Neurosci"},{"issue":"4","key":"e_1_2_13_10_1","first-page":"301","article-title":"The effects of lithium therapy on leukocytes: a 1\u2010year follow\u2010up study","volume":"85","author":"Carmen J","year":"1993","journal-title":"J Natl Med Assoc"},{"issue":"3","key":"e_1_2_13_11_1","first-page":"161","article-title":"Leukocytosis during lithium treatment and its correlation to serum lithium level","volume":"28","author":"Watanabe S","year":"1974","journal-title":"Folia Psychiatr Neurol Jpn"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt1971126923"},{"key":"e_1_2_13_13_1","first-page":"249","article-title":"Dose equivalence of psychotropic drugs. Part X VII: dose equivalence of novel antipsychotics: aripiprazole. Jap","volume":"9","author":"Inagaki A","year":"2006","journal-title":"J Clin Psychopharmacol"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.5649\/jjphcs.41.355"},{"volume-title":"Psychiatry clinical pharmacy","year":"2013","author":"Yukihiro N","key":"e_1_2_13_15_1"},{"issue":"4","key":"e_1_2_13_16_1","first-page":"183","article-title":"Factors associated with high\u2010dose prescription of antipsychotics in outpatients with schizophrenia: An analysis of claims data from a Japanese prefecture","volume":"51","author":"Hidenobu O","year":"2014","journal-title":"J Jap Soc Healthcare Admin"},{"issue":"3","key":"e_1_2_13_17_1","first-page":"280","article-title":"The Effects of Co\u2010administration of Lithium and Antipsychotic Drugs on Serum lithium Concentration","volume":"50","author":"Yusuke F","year":"2014","journal-title":"J Jap Soc Hosp Pharmacists"},{"key":"e_1_2_13_18_1","article-title":"A study on the steady\u2010state pharmacokinetics and safety of lithium in adult psychotic patients taking lithium in combination with risperidone or with other antipsychotic agents","author":"Demling J","year":"1997","journal-title":"Clinical Study Report\u2010RIS\u2010GER\u20109"}],"container-title":["Neuropsychopharmacology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/npr2.12210","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/npr2.12210","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/npr2.12210","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T02:45:10Z","timestamp":1693190710000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/npr2.12210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,22]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1002\/npr2.12210"],"URL":"https:\/\/doi.org\/10.1002\/npr2.12210","archive":["Portico"],"relation":{},"ISSN":["2574-173X","2574-173X"],"issn-type":[{"type":"print","value":"2574-173X"},{"type":"electronic","value":"2574-173X"}],"subject":[],"published":{"date-parts":[[2021,10,22]]},"assertion":[{"value":"2021-07-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}