{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T15:47:17Z","timestamp":1783352837079,"version":"3.54.6"},"reference-count":4,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T00:00:00Z","timestamp":1644883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropsychopharm Rep"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Clozapine is an atypical antipsychotic used for treatment\u2010resistant schizophrenia and is known to cause serious side effects, such as leukopenia and neutropenia. We encountered the case of a 44\u2010year\u2010old female patient with a good response to clozapine, who experienced inflammatory reaction and cytopenia after coronavirus disease 2019 (COVID\u201019) vaccination. Soon after clozapine discontinuation, the inflammatory reaction resolved, and cell counts recovered. There are only a few reports on the interaction between clozapine and COVID\u201019 vaccine. Our findings suggest that caution is required when a patient who is receiving clozapine scheduled for COVID\u201019 vaccination, owing to the possibility of cytopenia. Moreover, blood tests and the measurement of clozapine concentration should be performed before and after the inoculation to ensure patient safety.<\/jats:p>","DOI":"10.1002\/npr2.12238","type":"journal-article","created":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T11:11:30Z","timestamp":1644923490000},"page":"238-240","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A case report: Clozapine\u2010induced leukopenia and neutropenia after mRNA COVID\u201019 vaccination"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6858-1145","authenticated-orcid":false,"given":"Tomoyuki","family":"Imai","sequence":"first","affiliation":[{"name":"Department of Neuropsychiatry Kumamoto University Hospital  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Ochiai","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Kumamoto University Hospital  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiro","family":"Ishimaru","sequence":"additional","affiliation":[{"name":"Comprehensive Clinical Education, Training and Development Center Kumamoto University  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayato","family":"Daitoku","sequence":"additional","affiliation":[{"name":"Minamata City General Hospital and Medical Center  Minamata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Miyagawa","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Kumamoto University Hospital  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuji","family":"Fukuhara","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Kumamoto University Hospital  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuken","family":"Boku","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Faculty of Life Science Kumamoto University  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9962-8444","authenticated-orcid":false,"given":"Minoru","family":"Takebayashi","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Kumamoto University Hospital  Kumamoto Japan"},{"name":"Department of Neuropsychiatry Faculty of Life Science Kumamoto University  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.210027"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2020.107627"},{"issue":"5","key":"e_1_2_8_4_1","first-page":"e4682","article-title":"A case of sudden very late onset of severe clozapine\u2010induced agranulocytosis following an influenza vaccine","volume":"11","author":"Jean S","year":"2019","journal-title":"Cureus"},{"key":"e_1_2_8_5_1","volume-title":"Clozaril Patient Monitoring Service (CPMS) standard operating procedures 5.0","author":"The Expert Committee for Clozaril Patient Monitoring Service","year":"2021"}],"container-title":["Neuropsychopharmacology 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