{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T06:52:10Z","timestamp":1788591130377,"version":"build-2803163510"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,2,19]],"date-time":"2022-02-19T00:00:00Z","timestamp":1645228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropsychopharm Rep"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Aripiprazole long\u2010acting injection (LAI) is approved for the treatment of schizophrenia in adults. Recently, Europe and Canada approved the use of the two\u2010injection start regimen: two separate injections of 400\u2010mg long\u2010acting aripiprazole along with a single 20\u2010mg dose of oral aripiprazole. Aripiprazole showed efficacy in the treatment of adolescents with acute schizophrenia in several controlled trials, leading to its approval for 13\u2010 to 17\u2010year\u2010old adolescents with schizophrenia by the EMA. However, the LAI formulation still remains off\u2010label in adolescents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>The patient was admitted to the General Psychiatry inpatient unit with a Positive and Negative Syndrome Scale (PANSS) total score of 136 and the Clinical Global Impression (CGI) score of 7. Aripiprazole was started and up\u2010titrated to 30\u00a0mg\/d. After 3\u00a0weeks, the positive symptoms were significantly reduced; however, he still showed prominent negative symptoms. Clozapine 100\u00a0mg\/d was added, and in the following 2\u00a0weeks, the patient appeared slightly more communicative and generally more aware of himself and the others. The PANSS total score decreased to 81. Due to poor insight, the patient was at\u2010risk not to take medications upon returning home; therefore, aripiprazole LAI was proposed. Since he urged to be discharged from the hospital, we opted for the two\u2010injection start. The medication was optimally tolerated, with no evidence of akathisia or other side effects. One month later, global functioning and illness insight improved; Positive and Negative Syndrome Scale score was 43 and CGI score 2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Aripiprazole LAI showed good efficacy and tolerability in an adolescent with schizophrenia. The two\u2010injection start regimen was a safe and effective option.<\/jats:p><\/jats:sec>","DOI":"10.1002\/npr2.12240","type":"journal-article","created":{"date-parts":[[2022,2,19]],"date-time":"2022-02-19T08:39:37Z","timestamp":1645259977000},"page":"241-244","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Aripiprazole LAI two\u2010injection start in a 16 year\u2010old adolescent with schizophrenia"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3374-018X","authenticated-orcid":false,"given":"Virginio","family":"Salvi","sequence":"first","affiliation":[{"name":"Department of Clinical Neurosciences\/DIMSC Universit\u00e0 Politecnica delle Marche  Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Appignanesi","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences\/DIMSC Universit\u00e0 Politecnica delle Marche  Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brodinela","family":"Marpepa","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences\/DIMSC Universit\u00e0 Politecnica delle Marche  Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Orsolini","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences\/DIMSC Universit\u00e0 Politecnica delle Marche  Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Volpe","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences\/DIMSC Universit\u00e0 Politecnica delle Marche  Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/070674371405901003"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsc.2019.10.014"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20822"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbq109"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2989\/17280583.2014.924416"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2016.0055"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/2045125314540297"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2017.06.013"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2008.07061035"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.12681"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/13.2.261"},{"key":"e_1_2_9_13_1","first-page":"218","volume-title":"ECDEU Assessment Manual for Psychopharmacology. 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