{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T18:37:29Z","timestamp":1766428649900,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T00:00:00Z","timestamp":1646179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropsychopharm Rep"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Supporting patients upon discharge following prolonged hospitalization in private psychiatric hospitals in Japan have long been an issue. This study evaluated the efficacy of clozapine in treating long\u2010stay patients with treatment\u2010resistant schizophrenia to reduce the frequency and duration of readmissions postdischarge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively examined the length and frequency of hospitalizations of long\u2010stay and non\u2010long\u2010stay patients with schizophrenia who were introduced to clozapine at our hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Comparing participants\u2019 medical records 2\u00a0years before and after the introduction of clozapine, we identified a significant decrease in both length and frequency of hospitalizations in all patients who were introduced to clozapine. In long\u2010stay patients, the length and frequency of hospitalization were significantly reduced. However, compared to non\u2010long\u2010stay patients, the period from introduction of clozapine to discharge was longer and the dose of clozapine was higher. Thus, it is necessary to take time to evaluate the therapeutic effects for long\u2010stay patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results showed that clozapine is helpful for patients with treatment\u2010resistant schizophrenia, who are considered difficult to treat and discharge in Japan.<\/jats:p><\/jats:sec>","DOI":"10.1002\/npr2.12244","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T10:49:02Z","timestamp":1646218142000},"page":"183-190","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy of clozapine for long\u2010stay patients with treatment\u2010resistant schizophrenia: 4\u2010year observational study"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3026-3990","authenticated-orcid":false,"given":"Kentaro","family":"Mizuno","sequence":"first","affiliation":[{"name":"Wakakusa Hospital  Miyazaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emiko","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Wakakusa Hospital  Miyazaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Suekane","sequence":"additional","affiliation":[{"name":"Emergency Department Miyazaki Prefectual Miyazaki Hospital  Miyazaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiaki","family":"Shiratsuchi","sequence":"additional","affiliation":[{"name":"Wakakusa Hospital  Miyazaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1988.01800330013001"},{"issue":"1","key":"e_1_2_12_3_1","first-page":"53","article-title":"The role of clozapine for deinstitutionalization of a private psychiatric hospital","volume":"23","author":"Kentaro M","year":"2020","journal-title":"Japanese J Clin Pharmacol"},{"key":"e_1_2_12_4_1","unstructured":"Ministry of Health Labour and Welfare.A guide for building a community\u2010based comprehensive care system that responds to mental disorders (2020 edition) (in Japanese). [Internet].c2020. [cited 2021 May 6]. Reference materials 8\u201010. Available fromhttps:\/\/www.mhlw\u2010houkatsucare\u2010ikou.jp\/ref.html#sec02"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000000904"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3371\/CSRP.6.3.5"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbt137"},{"key":"e_1_2_12_8_1","unstructured":"Ministry of Health Labour and Welfare.Revision of FY2018 medical fees; summary of the second revision: 1 (in Japanese). [Internet].c2020. [cited 2018 Feb 7]. 302\u2010303 p. Available fromhttps:\/\/www.mhlw.go.jp\/file\/05\u2010Shingikai\u201012404000\u2010Hokenkyoku\u2010Iryouka\/0000193708.pdf"},{"key":"e_1_2_12_9_1","unstructured":"Ministry of Health Labour and Welfare.Revision of FY2020 medical fees; summary of the second revision: 1 (in Japanese). [Internet].c2020. [cited 2020 Feb 7]. 162\u2010163 p. 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