{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T01:23:32Z","timestamp":1776821012496,"version":"3.51.2"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T00:00:00Z","timestamp":1656028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropsychopharm Rep"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although resistance to thyroid hormone beta (RTH\u03b2) is associated with attention\u2010deficit\/hyperactivity disorder, there are few reports of other concomitant mood disorders in individuals with RTH\u03b2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>A 67\u2010year\u2010old woman who had been previously diagnosed with RTH\u03b2 (Refetoff syndrome) came to our department as a depressed patient. She was hospitalized twice for depression and treated with antidepressants both times. Paroxetine (37.5\u00a0mg\/day) treatment during the first hospitalization did not cause any side effects, but treatment with mirtazapine (15\u2009mg\/day) and venlafaxine (150\u2009mg\/day) during the second hospitalization caused clonus and disturbance of consciousness, and these adverse effects resulted in a prolonged period of hospitalization. Finally, the patient\u2019s symptoms were controlled with quetiapine (75\u2009mg\/day).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Poor tolerability to antidepressants was observed, which may be related to thyroid hormone intolerance. Low doses of quetiapine may contribute to improvements in depression.<\/jats:p><\/jats:sec>","DOI":"10.1002\/npr2.12280","type":"journal-article","created":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T10:13:29Z","timestamp":1656065609000},"page":"391-394","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A case of mood disorder with severe side effects of antidepressants in association with resistance to thyroid hormone beta with a <scp>THRB<\/scp> mutation"],"prefix":"10.1002","volume":"42","author":[{"given":"Hazuki","family":"Komahashi\u2010Sasaki","sequence":"first","affiliation":[{"name":"Department of Psychiatry School of Medicine Dokkyo Medical University  Tochigi 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