{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:43:23Z","timestamp":1747151003094,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T00:00:00Z","timestamp":1658448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropsychopharm Rep"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>It is controversial whether psychotic features are a risk factor for relapse in patients with electroconvulsive therapy\u2010responsive major depressive disorder. A recent study reported that benzodiazepine receptor agonists reduce relapse of psychotic depression. As long\u2010term use of these agonists may induce dependence, further research is required. We examined whether psychotic features are associated with rehospitalization in electroconvulsive therapy\u2010responsive major depressive disorder patients. We also investigated whether taking benzodiazepine receptor agonists at the end of electro\u2010convulsive therapy was associated with rehospitalization among patients with psychotic depression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included 47 hospitalized patients (22 with psychotic depression, 25 with non\u2010psychotic depression) who had responded to electroconvulsive therapy. Rehospitalization for major depressive episodes within two years from the last session was investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010three subjects (49%) were rehospitalized during the two\u2010year follow\u2010up. Kaplan\u2013Meier analysis revealed no difference in rehospitalization between patients with psychotic and non\u2010psychotic depression (Log\u2010rank <jats:italic>P<\/jats:italic>\u00a0=\u00a00.87). Among the 22 responders to electroconvulsive therapy with psychotic depression, there was no difference in benzodiazepine receptor agonist use at the end of electroconvulsive therapy between the rehospitalization and non\u2010rehospitalization groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our exploratory study found no difference in the benzodiazepine receptor agonists use at the end of electroconvulsive therapy between rehospitalization and non\u2010rehospitalization groups in patients with electroconvulsive therapy\u2010responsive psychotic depression. Thus, the relapse\u2010preventing effect of these agonists in psychotic depression should be investigated in future randomized controlled trials. Further research is also needed to determine whether psychotic features are associated with rehospitalization in these patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/npr2.12282","type":"journal-article","created":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T09:03:00Z","timestamp":1658480580000},"page":"449-456","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Relationship among psychotic features, benzodiazepine receptor agonists, and rehospitalization in patients with electroconvulsive therapy\u2010responsive major depressive disorder: A retrospective <scp>2\u2010year<\/scp> observational study"],"prefix":"10.1002","volume":"42","author":[{"given":"Akise","family":"Umakoshi","sequence":"first","affiliation":[{"name":"Department of Neuropsychiatry Akita University Graduate School of Medicine  Akita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0614-7524","authenticated-orcid":false,"given":"Masahiro","family":"Takeshima","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Akita University Graduate School of Medicine  Akita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Itoh","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Akita University Graduate School of Medicine  Akita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Akita University Graduate School of Medicine  Akita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nana","family":"Shibata","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Akita University Graduate School of Medicine  Akita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6060-375X","authenticated-orcid":false,"given":"Masaya","family":"Ogasawara","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Akita University Graduate School of Medicine  Akita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Ayabe","sequence":"additional","affiliation":[{"name":"Department of Regional Studies and Humanities, Faculty of Education and Human Studies Akita University  Akita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1182-1181","authenticated-orcid":false,"given":"Kazuo","family":"Mishima","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Akita University Graduate School of Medicine  Akita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,22]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291717002501"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1991.01810360039006"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2018.17101138"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12991-018-0207-1"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.4306\/pi.2014.11.3.281"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00124509-200112000-00003"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.155.2.178"},{"key":"e_1_2_14_10_1","unstructured":"American Psychiatric Association.2010.Practice Guideline for the Treatment of Major Depressive Disorder 3rd ed. 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