{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:50:53Z","timestamp":1786978253850,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T00:00:00Z","timestamp":1658275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropsychopharm Rep"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Pharmacological treatments recommended for bipolar depression are inconsistent across guidelines. We compared the efficacy and safety of antipsychotics and mood stabilizers for bipolar depression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systemic review and meta\u2010analysis of randomized controlled trials comparing antipsychotics and mood stabilizers for bipolar depression was conducted based on a literature search of major electronic databases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Three studies comparing quetiapine with lithium were identified and analyzed; no other antipsychotic\u2010mood stabilizer combinations were found. The meta\u2010analysis revealed no significant differences between quetiapine and lithium for the following outcomes: (1) remission from depressive episodes (risk ratio [RR]: 1.80, 95% CI: 0.51\u20106.40,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.36), (2) changes in depressive symptom (standardized mean difference: \u22120.22, 95% CI: \u22120.52\u20100.08,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.15), (3) changes in social function (standardized mean difference: \u22120.00, 95% CI: \u22120.19\u20100.18,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.98), (4) suicide\u2010related events (odds ratio [OR]: 2.35, 95% CI: 0.40\u201013.65,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.34), (5) severe adverse events (OR: 1.63, 95% CI: 0.51\u20105.20,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.41), (6) dropouts due to adverse events (RR: 1.19, 95% CI: 0.76\u20101.87,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.45, 7) dropout for any reasons (RR: 0.95, 95% CI: 0.74\u20101.22,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.70)\n                      <jats:bold>.<\/jats:bold>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although this study found no differences in the efficacy and safety of quetiapine and lithium for bipolar depression, a comprehensive comparison of antipsychotics and mood stabilizers was not performed. Further studies are needed to clarify which of these, not just quetiapine and lithium, is more useful for bipolar depression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/npr2.12283","type":"journal-article","created":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T20:20:12Z","timestamp":1658348412000},"page":"410-420","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Comparison of the efficacy and safety of quetiapine and lithium for bipolar depression: A systematic review and meta\u2010analysis of randomized controlled trials"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6060-375X","authenticated-orcid":false,"given":"Masaya","family":"Ogasawara","sequence":"first","affiliation":[{"name":"Department of Neuropsychiatry Akita University Graduate School of Medicine  Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0614-7524","authenticated-orcid":false,"given":"Masahiro","family":"Takeshima","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Akita University Graduate School of Medicine  Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5165-6171","authenticated-orcid":false,"given":"Yuichi","family":"Esaki","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Okehazama Hospital  Aichi Japan"},{"name":"Department of Psychiatry Fujita Health University School of Medicine  Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Nihon University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4673-7230","authenticated-orcid":false,"given":"Tomohiro","family":"Utsumi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2674-0707","authenticated-orcid":false,"given":"Yumi","family":"Aoki","sequence":"additional","affiliation":[{"name":"Psychiatric &amp; Mental Health Nursing St.Luke\u2019s International University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Soseikai General Hospital  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3873-8727","authenticated-orcid":false,"given":"Masahiro","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Nihon University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9169-3249","authenticated-orcid":false,"given":"Yoshikazu","family":"Takaesu","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Faculty of Medicine University of the Ryukyus  Okinawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,20]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.12"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2007.00467.x"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.59.6.530"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.3.261"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12271"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2018.12.057"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v68n0811"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.13191"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.12852"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2006.163.9.1561"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2008.00581.x"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2005.08.001"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2008.01201.x"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.13163"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.13198"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00241-X"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12609"},{"key":"e_1_2_14_19_1","unstructured":"Japanese Society of Mood Disorders.Japanese Society of Mood Disorders guidelines I. 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