{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T13:39:56Z","timestamp":1762609196823,"version":"3.40.5"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T00:00:00Z","timestamp":1677456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropsychopharm Rep"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Antidepressant\u2010induced jitteriness\/anxiety syndrome is characterized as anxiety, agitation, panic attacks, insomnia, irritability, hostility, aggressiveness, impulsivity, akathisia, and (hypo)mania, which appear immediately after initiation or increased dosage of an antidepressant. This report describes a case of the jitteriness\/anxiety syndrome caused by the coadministration of celecoxib with escitalopram and trazodone in a patient with depression and spondylolisthesis. The depression of a patient, a woman in her 60\u2009s, had been in remission at least for 5\u2009years under treatment using escitalopram and trazodone. Immediately after coadministration of celecoxib because of her buttock and limb pain, she showed anxiety, agitation, akathisia, insomnia, irritability, aggressiveness, impulsivity, and hypomania. These symptoms disappeared after the discontinuation of celecoxib. The present case suggests that coadministration of celecoxib with escitalopram and trazodone can cause the jitteriness\/anxiety syndrome, presumably via a pharmacokinetic interaction of celecoxib with these antidepressants and\/or the effects of celecoxib on serotonergic neurotransmission.<\/jats:p>","DOI":"10.1002\/npr2.12325","type":"journal-article","created":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T11:19:06Z","timestamp":1677496746000},"page":"264-266","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Jitteriness\/anxiety syndrome caused by coadministration of celecoxib, a selective <scp>COX<\/scp>\u20102 inhibitor, with escitalopram and trazodone in a patient with depression and spondylolisthesis"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9118-0363","authenticated-orcid":false,"given":"Toshinori","family":"Shirata","sequence":"first","affiliation":[{"name":"Department of Psychiatry Yamagata University School of Medicine  Yamagata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Yano","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yamagata University School of Medicine  Yamagata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Noto","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yamagata University School of Medicine  Yamagata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muneaki","family":"Kanno","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yamagata University School of Medicine  Yamagata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihito","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yamagata University School of Medicine  Yamagata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,2,27]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cppeds.2017.12.001"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.20438"},{"volume-title":"Worsening depression and suicidality in patients being treated with antidepressants","year":"2004","author":"Food and Drug Administration","key":"e_1_2_14_4_1"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dmpk.2018.06.001"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1178646919873925"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02245462"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9236(03)00120-6"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200746040-00002"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-006-0111-0"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-199508000-00003"},{"volume-title":"Clinical manual of drug interaction: principles for medical practice","year":"2009","author":"Wynn GH","key":"e_1_2_14_13_1"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200502000-00026"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hup.2401"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2012.06.003"}],"container-title":["Neuropsychopharmacology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/npr2.12325","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/npr2.12325","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/npr2.12325","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T05:08:43Z","timestamp":1692508123000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/npr2.12325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,27]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1002\/npr2.12325"],"URL":"https:\/\/doi.org\/10.1002\/npr2.12325","archive":["Portico"],"relation":{},"ISSN":["2574-173X","2574-173X"],"issn-type":[{"type":"print","value":"2574-173X"},{"type":"electronic","value":"2574-173X"}],"subject":[],"published":{"date-parts":[[2023,2,27]]},"assertion":[{"value":"2022-12-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}