{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T18:48:58Z","timestamp":1794077338194,"version":"4.8.0"},"reference-count":66,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T00:00:00Z","timestamp":1688083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005001","name":"Ahvaz Jundishapur University of Medical Sciences","doi-asserted-by":"publisher","award":["NRC\u20109625"],"award-info":[{"award-number":["NRC\u20109625"]}],"id":[{"id":"10.13039\/501100005001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropsychopharm Rep"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>N\u2010acetylcysteine (NAC), a thiol\u2010containing antioxidant and glutathione (GSH) precursor, attenuates oxidative stress, and possibly improves psychiatric disorders. This study aimed to evaluate the effects of oral NAC on oxidative stress, depression, and anxiety symptoms in patients with multiple sclerosis (MS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This clinical trial was conducted on 42 MS patients randomly assigned to intervention (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200921) and control (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200921) groups. The intervention group received 600\u2009mg of NAC twice daily for 8\u2009weeks, and the control group received a placebo with the same prescription form. An analysis of serum malondialdehyde (MDA), serum nitric oxide (NO), and erythrocyte GSH was carried out on both groups, along with a complete blood count. The Hospital Anxiety and Depression Scale (HADS) was used to assess symptoms of depression (HADS\u2010D) and anxiety (HADS\u2010A).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared to the control group, NAC consumption significantly decreased serum MDA concentrations (\u22120.33 [\u22125.85\u20132.50] vs. 2.75 [\u22120.25\u20135.22] \u03bcmol\/L;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03) and HADS\u2010A scores (\u22121.6\u2009\u00b1\u20092.67 vs. 0.33\u2009\u00b1\u20092.83;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02). No significant changes were observed in serum NO concentrations, erythrocyte GSH levels, and HADS\u2010D scores (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Based on the findings of the present study, NAC supplementation for 8\u2009weeks decreased lipid peroxidation and improved anxiety symptoms in MS patients. The aforementioned results suggest that adjunctive therapy with NAC can be considered an effective strategy for MS management. Further randomized controlled studies are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/npr2.12360","type":"journal-article","created":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T03:19:24Z","timestamp":1688095164000},"page":"382-390","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Effects of N\u2010acetylcysteine on oxidative stress biomarkers, depression, and anxiety symptoms in patients with multiple sclerosis"],"prefix":"10.1002","volume":"43","author":[{"given":"Golsa","family":"Khalatbari\u00a0Mohseni","sequence":"first","affiliation":[{"name":"Nutrition and Metabolic Diseases Research Center Ahvaz Jundishapur University of Medical Sciences  Ahvaz Iran"},{"name":"Department of Nutrition, School of Allied Medical Sciences Ahvaz Jundishapur University of Medical Sciences  Ahvaz 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