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There were studies showing that the phospholipid abnormalities in subjects with schizophrenia (Front Biosci, S3, 2011, 153; Schizophr Bull, 48, 2022, 1125; Sci Rep, 7, 2017, 6; Anal Bioanal Chem, 400, 2011, 1933). Disturbances in prefrontal cortex phospholipid and fatty acid composition have been reported in subjects with schizophrenia (Sci Rep, 7, 2017, 6; Anal Bioanal Chem, 400, 2011, 1933; Schizophr Res, 215, 2020, 493; J Psychiatr Res, 47, 2013, 636; Int J Mol Sci, 22, 2021). For exploring the signaling pathways contributing to the lipid changes in previous study (Sci Rep, 7, 2017, 6), we performed two types of transcriptome analyses in subjects with schizophrenia: an unbiased transcriptome analysis solely based on RNA\u2010seq data and a correlation analysis between levels of gene expression and lipids.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>RNA\u2010Seq analysis was performed in the postmortem prefrontal cortex from 10 subjects with schizophrenia and 5 controls. Correlation analysis between the transcriptome and lipidome from 9 subjects, which are the same samples in the previous lipidomics study (Sci Rep, 7, 2017, 6).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Extraction of differentially expressed genes (DEGs) and further sequence and functional group analysis revealed changes in gene expression levels in phosphoinositide 3\u2010kinase (PI3K)\u2010Akt signaling and the complement system. In addition, a correlation analysis clarified alterations in ether lipid metabolism pathway, which is not found as DEGs in transcriptome analysis alone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study provided results of the integrated analysis of the schizophrenia\u2010associated transcriptome and lipidome within the PFC and revealed that lipid\u2010correlated alterations in the transcriptome are enriched in specific pathways including ether lipid metabolism pathway.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/npr2.12368","type":"journal-article","created":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T10:39:26Z","timestamp":1690454366000},"page":"403-413","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Lipid\u2010correlated alterations in the transcriptome are enriched in several specific pathways in the postmortem prefrontal cortex of Japanese patients with schizophrenia"],"prefix":"10.1002","volume":"43","author":[{"given":"Wataru","family":"Arihisa","sequence":"first","affiliation":[{"name":"Department of Cellular and Molecular Anatomy Hamamatsu University School of Medicine  Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Anatomy Hamamatsu University School of Medicine  Shizuoka Japan"},{"name":"International Mass Imaging Center Hamamatsu University School of Medicine  Shizuoka Japan"},{"name":"Department of Biochemistry, Faculty of Medicine and Graduate School of Medicine Hokkaido University  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsushi","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"National Institute for Basic Biology  Okazaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4228-3208","authenticated-orcid":false,"given":"Junya","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, School of Medicine Fukushima Medical University  Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Nakanishi","sequence":"additional","affiliation":[{"name":"Research Center for Biosignal Akita University  Akita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuto","family":"Kunii","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, School of Medicine Fukushima Medical University  Fukushima Japan"},{"name":"Department of Disaster Psychiatry International Research Institute of Disaster Science, Tohoku University  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyasu","family":"Akatsu","sequence":"additional","affiliation":[{"name":"Choju Medical Institute, Fukushimura Hospital  Toyohashi Japan"},{"name":"Department of Community\u2010based Medical Education\/Department of Community\u2010based Medicine Nagoya City University Graduate School of Medical Science  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3700-0322","authenticated-orcid":false,"given":"Mizuki","family":"Hino","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, School of Medicine Fukushima Medical University  Fukushima Japan"},{"name":"Department of Disaster Psychiatry International Research Institute of Disaster Science, Tohoku University  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshio","family":"Hashizume","sequence":"additional","affiliation":[{"name":"Choju Medical Institute, Fukushimura Hospital  Toyohashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shumpei","family":"Sato","sequence":"additional","affiliation":[{"name":"RIKEN Center for Biosystems Dynamics Research  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Sato","sequence":"additional","affiliation":[{"name":"Business Development, Otsuka Pharmaceutical Co., Ltd. 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