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Using mice with excitatory neuron\u2010specific deletion of VEGF and its receptor, fetal liver kinase 1 (Flk\u20101) in the forebrain, we examined the effects of forebrain excitatory neuron\u2010specific deletion of VEGF or Flk\u20101 on the antidepressant\u2010like effects of repeated DMI and chronic FLX administration in the forced swim test (FST). Repeated intraperitoneal (i.p.) injections of DMI (10, 10, and 20\u2009mg\/kg at 24, 4, and 1\u2009h before the FST, respectively) significantly decreased immobility in control mice; however, this effect was completely blocked in mice with neuron\u2010specific VEGF or Flk\u20101 deletion. Although chronic treatment with FLX (18\u2009mg\/kg\/day, i.p.) did not impact immobility in control mice 1\u2009day after the 22nd injection, immobility was significantly reduced 1\u2009day after the preswim and the 23rd FLX injection. However, in mice with neuron\u2010specific Flk\u20101 deletion, chronic FLX treatment significantly increased immobility in the preswim and failed to produce antidepressant\u2010like effects. Collectively, these findings indicate that neuronal VEGF\u2013Flk\u20101 signaling contributes to the antidepressant\u2010like actions of conventional antidepressants.<\/jats:p>","DOI":"10.1002\/npr2.12393","type":"journal-article","created":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T07:20:00Z","timestamp":1699946400000},"page":"246-249","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Neuron\u2010specific deletion of <scp>VEGF<\/scp> or its receptor Flk\u20101 occludes the antidepressant\u2010like effects of desipramine and fluoxetine in mice"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5502-9746","authenticated-orcid":false,"given":"Satoshi","family":"Deyama","sequence":"first","affiliation":[{"name":"Department of Psychiatry Yale University School of Medicine  New Haven Connecticut USA"},{"name":"Laboratory of Molecular Pharmacology, Institute of Medical, Pharmaceutical and Health Sciences Kanazawa University  Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Yuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald S.","family":"Duman","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.68"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.03.033"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.02.063"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2019.172837"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2022.109335"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0610282104"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2018.12.014"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2018.17121368"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2019.11.002"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2018"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.126.6.1149"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.09.019"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300433"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2020.112844"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-022-01943-9"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-022-01337-1"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2012.01.023"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.14630"},{"key":"e_1_2_10_20_1","unstructured":"World Health Organization.Depressive disorder (depression).2023.https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/depression\/"}],"container-title":["Neuropsychopharmacology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/npr2.12393","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T05:58:07Z","timestamp":1732773487000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/npr2.12393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,13]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1002\/npr2.12393"],"URL":"https:\/\/doi.org\/10.1002\/npr2.12393","archive":["Portico"],"relation":{},"ISSN":["2574-173X","2574-173X"],"issn-type":[{"value":"2574-173X","type":"print"},{"value":"2574-173X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,13]]},"assertion":[{"value":"2023-09-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}